اثر سایپروهپتادین (CYP) بر میزان گلوکز خون و گلیکوژن کبدی در موش های صحرایی (رت)

Background and Purpose: Çyproheptadine (ÇYP) is an antihistaminic and antiserotonine agent with specific property which differentiates it from the other antihistaminics and antiserotonic agent. The appetite stimulating effect of (ÇYP) is well documented in man but its effects on the blood glucose and liver glycogen are not the same. Hence this study was conducted to determine the effects of different doses of (ÇYP) on the level of blood glucose and liver glycogen. Materials and Methods: Ïn this study a group of 28 rats with weight of 95 grams were selected, in order to determine the effect of different doses of (ÇYP) on the blood glucose and liver glycogen, the animals were divided into five groups as a control and four experimental groups. Ëach groups was kept in separate animal cages. The rats of experimental groups were fed 2.5, 5, 10, 20 mg of (ÇYP) per Kg of body weight daily for 14 days and the effect was determined on the level of blood glucose and liver glycogen. Statistical analysis was done with the help of Ânova test. Results: the level of glucose in control group and the experimental groups Ï,e 2,3,4 and 5 were 82.39, 110.32, 109.4, 120.54 and 121.54 mg per 100 ml respectivley which showes a significant difference between the groups F=4.43, P=0.008. The level of liver glycogen in control group and the experimental groups Ï,e 2,3,4 and 5 were 142.86, 83.06, 7.92, 9.13 and 26.1 mg per gram of liver tissue. There was significant difference between the groups F=26.88, P=0.000 Çonclusion: The results of this study showed that the effect of (ÇYP) on glucose and liver glycogen level is hyperglycemia with a reduction in the level of glycogen in liver tissue