اثر اسانس مرزه بر انقباضات ناشی از استیل‌کولین در ایلئوم موش صحرایی نر

Background and Objective: It has been used medicinal herbs for treatment of different abnormalities in traditional medication. One of these herbal medicine used in Iranian traditional medicine is Satureja that many biological studies conducted for determination of its pharmacological properties. Due to many reports around the effect of above-mentioned herb on gastrointestinal system, this present study was designed to find out the effects of Satureja essence on mechanical activity of the isolated rat’s ileum. Materials and Methods: In this study, by using an physiograph device, the spasmolytic property of Satureja essence with concentration of 25, 50, 100 & 200 ng/ml were recorded on ileum isotonic contraction induced by acetylcholine10-4 M. Results: Our findings showed that Satureja essence with concentration of less than 100 ng/ ml has no effect on acetylcholine 10-4 M induced contraction in rat’s ileum but the higher concentration of essense reduced acetylcholine-induced contraction which is statistically significant p<0.05. These effects as compared to positive control of carvacrol is not significant. Conclusion: Satureja essence significantly reduced acetylcholine (10-4 M) induced contraction therefore this essence may be useful for reduction of small intestine disorders. Key words: Satureja essence, Spasmolytic, Acetylcholine,Ileum,Smooth muscle.   Funding: This research was funded by Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran. Conflict of interest: None declared. Ethical approval: The research committee of Shahid Sadoughi University of Medical Sciences and Health Services approved the study.   How to cite this article: Hejazian SH, Bameri M, Bagheri SM,. Abbassi Sarcheshmeh A. The Effect of Satureja Essence on Acetylcholine-Induced Contraction in Male Rat’s Ileum. J RafsanjanUniv Med Sci 2014 13(4): 395-404. [Farsi]