آدنوزین منوفسفات حلقوی ( Cyclic AMP )
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The cyclic AMP pathway.
Cyclic adenosine 3′,5′-monophosphate (cAMP) was the first second messenger to be identified and plays fundamental roles in cellular responses to many hormones and neurotransmitters (Sutherland and Rall 1958). The intracellular levels of cAMP are regulated by the balance between the activities of two enzymes (see Fig. 1): adenylyl cyclase (AC) and cyclic nucleotide phosphodiesterase (PDE). Diffe...
full textCyclic AMP signalling.
Cyclic adenosine 3′,5′-monophosphate (cAMP) was the first identified second messenger. A large number of studies during the past 30 years have elucidated the fundamental role of cAMP in the cellular response to many hormones and neurotransmitters. Although the main components in the cAMP-mediated signalling pathway are well known, recently new important players have been identified, which have ...
full textCyclic AMP-induced conformational change of cyclic AMP receptor protein (CRP): intragenic suppressors of cyclic AMP-independent CRP mutations.
We isolated and characterized crp mutations in Escherichia coli that allow cyclic AMP (cAMP) receptor protein to function without cAMP. These mutants defined a region involved in the cAMP-induced allosteric change of cAMP receptor protein that is necessary for activation of the protein. Currently, we have isolated intragenic suppressors of the crp mutations. These crp (Sup) mutants require cAMP...
full textIs Independent of Cyclic AMP
Infusion of forskolin, an adenylate cyclase activator, in concentrations (2 ,uM) that do not alter basal prostaglandin (PG) synthesis inhibit synthesis of PG elicited by isoproterenol in rabbit heart. This inhibitory action of forskolin appears to be dependent on cyclicAMP (cAMP). Bolus injection of forskolin (75 nmol), however, was found to stimulate PG synthesis in rabbit heart. The purpose o...
full textCyclic AMP Receptors of Dictyostelium
P0005 When confronted with starvation, the social amoeba Dictyostelium discoideum survives by undergoing multicellular development and sporulation. The coordination of these processes is achieved in part through intercellular communication using secreted adenosine 30,50-cyclic monophosphate (cAMP) and a family of cell-surface cAMP receptors (cARs). The cARs are examples of G protein-coupled rec...
full textThe Epidermis and Cyclic Amp
A hormone induces a rapid and profound change in the metabolic balance of its target organ. Early studies emphasized the extraordinarily low concentrations in which many hormones are effective. The fact that catechoiamines and polypeptides are frequently unable to penetrate the surface of cells made this seem all the more remarkable. The mechanism of their action, which for many years remained ...
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Journal title
volume 29 issue None
pages 15- 18
publication date 1971-04
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