effect of bunium persicum aqueous extract plus endurance exercise on cardiorespiratory capacity and serum lipid profile

objective(s): we examined the effects of endurance exercise in the presence of bunium persicum extract administration on lipid profile and cardiorespiratory capacity in hypercholesterolemic male mice. materials and methods: forty male hypercholesterolemic mice were divided into four groups: vehicle, endurance exercise (ee), bunium persicum extract (bpe), and ee + bpe. the exercise protocol was performed at a speed of 18 m/min, 40 min/day, and 5 days/week for 6 weeks. the bpe was administered orally by a dose of 20 mg/kg/day. results: the results indicated that the 6-week endurance training accompanied by bunium persicum extract administration increased cardiorespiratory capacity significantly (601±39 vs. 293±20 meters, p<0.001). total cholesterol level was significantly reduced in ee + bpe compared with vehicle and ee groups (p<0.05). ldl-c was lower in ee + bpe compared with the vehicle (p<0.01). hdl-c in bpe and ee + bpe groups was significantly higher than vehicle (pconclusion: the results suggested that bunium persicum extract is very useful in improvement of lipid profile in hypercholesterolemic animals. supplementation of the extractto exercise significantly increased the cardiorespiratory capacity.