study on immunity of an experimental oil adjuvant haemorrhagic septicaemia vaccine in cattle.
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abstract
an oil adjuvant vaccine (oav) was prepared from a local strain of pasteurella multocida. strain 6:b was cultured and inactivated by formalin. bacterial pellet was prepared by centrifugation and subsequently adjuvanted by montannide oil isa-70. a dose of prepared vaccine containing 3ml (2mg dry weight/ml) was injected into five calves by im route. animals were bled before and at 24, 90, 150, and 200 days post-vaccination. collected sera were used in passive mouse protection test (pmpt). active mouse protection test (ampt) was carried out for oav according to standard method. results of pmpt showed 100% protection up to 150 days and 66-83% up to 200 days post-vaccination. in ampt, 4 log of protection was gained. in this experiment the immunity induced by oav adjuvanted by isa-70 could protect the calves.
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Journal title:
archives of razi institutePublisher: razi vaccine & serum research institute (rvsri)
ISSN 0365-3439
volume 59
issue 1 2016
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