adverse effects of long-time exposure to formaldehyde vapour on testicular tissue and sperm parameters in rats
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abstract
formalin is widely used in industry and in medicine (as tissue fixative and disinfectant).it contains reactive molecules which have been known for its cytotoxic effects. to evaluate the effect of formalin exposure on the testicular tissue and sperm parameter from neonatal period through physical and sexual maturity, 28 male wister rats were assigned into two equal test and control groups. the test group was exposed to 1.5 ppm of the vapour of 10% formaldehyde in a special chamber for 2 hr per day at 20-26 ˚c and the air pressure of 760-763 atm. after 55 days, the tubular differentiation (tdi) and repopulation (ri) indexes in testicular tissue, sperm quality parameters, serum total antioxidant capacity and testosterone level were determined. the formaldehyde-exposed animals showed severe seminiferous tubules atrophy, edematous connective tissue, arrested spermatogenesis with negative tdi and ri and vascular thrombosis compared to control group. histomorphological studies showed a high sperm mortality and abnormality associated with a remarkable decrease in sperm count. formaldehyde-exposed animals revealed with decreased serum level of testosterone (p < 0.05) and down-regulated antioxidant status versus control group. in conclusion, the current data provide inclusive histological and biochemical information about the chronic exposure to formaldehyde with emphasizing on reproductive disorders including histological adverse effects on the testicular tissue, spermatogenesis, sperm viability, count and the abnormalities which can potentially cause infertility after sexual maturation.
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Adverse effects of long-time exposure to formaldehyde vapour on testicular tissue and sperm parameters in rats
Formalin is widely used in industry and in medicine (as tissue fixative and disinfectant).It contains reactive molecules which have been known for its cytotoxic effects. To evaluate the effect of formalin exposure on the testicular tissue and sperm parameter from neonatal period through physical and sexual maturity, 28 male Wister rats were assigned into two equal test and control groups. The t...
full textAdverse effects of long-time exposure to formaldehyde vapour on testicular tissue and sperm parameters in rats
Formalin is widely used in industry and in medicine (as tissue fixative and disinfectant).It contains reactive molecules which have been known for its cytotoxic effects. To evaluate the effect of formalin exposure on the testicular tissue and sperm parameter from neonatal period through physical and sexual maturity, 28 male Wister rats were assigned into two equal test and control groups. The t...
full texteffects of simultaneous exposure to formaldehyde vapor and noise on mouse testicular tissue and sperm parameters
conclusions exposure to formaldehyde vapor can destroy testicular structure and decrease percentages of sperm count and progressive motility. the present study indicated that a reduction in the percentage of progressive motile sperm may be potentiated by noise (700-5700 hz) in the simultaneous exposure to formaldehyde and noise group. thus, it can be anticipated that simultaneous exposure to fo...
full textAdverse Effects of Formaldehyde Vapor on Mouse Sperm Parameters and Testicular Tissue
BACKGROUND Formaldehyde (FA), one of the simplest organic molecules, is a flammable, pungent, irritating and colorless gas. This study aimed to investigate the effects of various concentrations of FA vapor on sperm parameters and testicular tissue. MATERIALS AND METHODS In this experimental study, we randomly assigned 36 adult male mice to one control and two experimental groups (n=12 for eac...
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Journal title:
veterinary research forumPublisher: faculty of veterinary medicine, urmia university
ISSN 2008-8140
volume 4
issue 4 2013
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