esophageal carcinoma: long-term survival in consecutive series of patients through a retrospective cohort study

normal 0 false false false en-us x-none ar-sa microsoftinternetexplorer4 aim : the present study aimed to investigate the influence of histological factors on survival of patients with esophageal cancer. background : esophageal cancer is almost the common form of malignancy in the eastern world. patients and methods : through a retrospective cohort study a consecutive series of 134 patients with definite diagnosis of esophageal cancer who had been hospitalized at the towhid hospital, sanandaj city, kurdistan province western iran during a five-year period from 2006 onward were recruited. the survival time of patients stratified by this grouping method were analyzed by kaplan-meier analysis and cox regression. results : overall, 127 males (55.1%), with a mean age of 65.38 ±11.62 years were included. based on histological type of tumor, 23 patients (18 . 1%) had adenocarcinoma (ac) and 94 patients (74 . 0%) had squamous cell carcinoma (scc). gender was not significantly associated with survival (log rank =0.480). location of tumor (log rank=0.014), histological type (log rank ?0.001) and grade of tumor (log rank =0.008) had significantly influenced the survival rates variation. for patients at initial stages of the disease, the overall one-year, two years and five years survival rates were 73.2%, 52.8% and 31.2% respectively. for advanced stages, the survival ranged from 46.3% in the first year to 8.2% in the five years. the five-year survival rates (by year) were estimated to be 49%, 27%, 24%, 22% and 19% respectively. conclusion : tumor grade, tumor deferential, clinical staging and location of the tumor were the prognostic factors for survival in patients with esophageal cancer.