maternal serum levels of transforming growth factor ß1 (tgf-ß1) in normal and preeclamptic pregnancies
Authors
abstract
background: successful pregnancy in allopregnant women depends upon the control of graft rejection mechanisms. it has been suggested that some immunosuppressive cytokines contribute to successful pregnancy and transplantation. transforming growth factor beta (tgf- β) exhibits potent immunoregulatory and anti-inflammatory properties which might prolong graft survival. recent studies suggest a role for tgf- β in the generation of t-regulatory lymphocytes which preserves the tolerance to peripheral self antigens and may control the response to allogenic tissues and thereby promote the transplantation tolerance. also, the function of tgf- β in trophoblast differentiation and hypertension is reported. objective: to evaluate the maternal serum tgf- β1 level in normal allopregnant women and in pregnancies complicated by preeclampcia (pe). methods: sixty one pregnant preeclamptic women (32 cases with severe and 29 with mild pe), 22 normotensive healthy pregnant, and 20 non-pregnant controls constituted the studied groups. the active form of tgf- β1 in serum from all cases was investigated by indirect elisa technique. results: the results showed that tgf- β1 level was higher in all three pregnant groups as compared with the nonpregnant controls. no significant changes in serum levels of tgf- β1 were found in pe as compared with the normal pregnancy. conclusion: tgf-β1 may function as a regulatory factor in fetal allograft survival during pregnancy, and tgf- β1 does not have a pathophysiological role in pe.
similar resources
Maternal Serum Levels of Transforming Growth Factor ß1 (TGF-ß1) in Normal and Preeclamptic Pregnancies
Background: Successful pregnancy in allopregnant women depends upon the control of graft rejection mechanisms. It has been suggested that some immunosuppressive cytokines contribute to successful pregnancy and transplantation. Transforming growth factor beta (TGF- β) exhibits potent immunoregulatory and anti-inflammatory properties which might prolong graft survival. Recent studies suggest a ...
full textComparison of thyroid hormone levels between normal and preeclamptic pregnancies
Background: To investigate thyroid function in preeclamptic patients in comparison with normal pregnant women. Methods: In this analytical cross-sectional study free Thyroxine (T4), and Thyroid Stimulating Hormone (TSH) levels were measured in 100 preeclamptic patients and were compared with Free T4 and TSH levels in 101 normal pregnant women in their third trimester of pregnancy. Patient...
full textRelationship between serum transforming growth factor ß1 and liver collagen content in rats treated with carbon tetrachloride.
CONTEXT Transforming Growth Factor ß1 (TGFß1) plays a fundamental role in fibrogenesis, although its importance as a biomarker of liver disease is still matter of debate. OBJECTIVE Quantify serum TGFß1 and its association to liver collagen content in rats exposed to Carbon Tetrachloride (CCl4). METHODS Rats were submitted to a fibrosis model using CCl4 and sacrificed after 6, 10, 12 and 16 ...
full textShear-Induced Activation of Latent TGF-ß1 in Synovial Fluid
INTRODUCTION: Transforming growth factor beta (TGF-β) is a ubiquitous multifunctional cytokine that modulates the growth, differentiation, and proliferation of most cell types. In cartilage, TGF-β has been shown to directly influence DNA and protein synthesis [1,2]. Additionally, TGF-β is believed to be present in synovial fluid [3,4] as well as released by chondrocytes as an autocrine regulato...
full textSerum Level of High Sensitive C-Reactive Protein in Normal and Preeclamptic Pregnancies
Background and Objective: The aim of this study was to determine the level of plasma high sensitive c-reactive protein (hs-CRP) in preeclampsia and to compare hs-CRP levels between normal pregnant women, mild preeclamptic, and severe preeclamptic women. Materials and Methods: Serum hs-CRP levels were inv...
full textMy Resources
Save resource for easier access later
Journal title:
iranian journal of immunologyجلد ۲، شماره ۱، صفحات ۵۰-۵۵
Hosted on Doprax cloud platform doprax.com
copyright © 2015-2023