foxp3 and tgf-β gene polymorphisms in allergic rhinitis

Authors

haddi hassannia

department of immunology and microbiology saeid abediankenari

department of immunology and microbiology javad ghaffari

department of pediatrics, mazandaran university of medical sciences, sari, iran

abstract

background: regulatory cd4+t (treg) cells are effective in maintaining immune tolerance. objective: to investigate single nucleotide polymorphisms (snps) of transforming growth factor β-1 (tgf-β1) and forkhead box protein 3 (foxp3) genes in iranian patients with allergic rhinitis (ar). methods: variations at codons 10 and 25 of tgf-β1 and foxp3 at positions -3279 a>c and -924 a>g were evaluated in ar patients and compared with controls. in a case-control study, 155 ar patients and 163 allergy- free controls were genotyped using polymerase chain reaction sequence-specific primer (pcr-ssp) technique. results: the analysis of the frequency of these snps showed that the haplotype formed by foxp3 -3279 a allele occurred significantly more frequently in patients than controls (odds ratio=1.44, 95% ci=1.312-2.66; p=0.001). conclusion: our results suggest that polymorphism in foxp3 gene is associated with susceptibility to ar.

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Journal title:
iranian journal of immunology

جلد ۸، شماره ۴، صفحات ۲۱۸-۲۲۵

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