analysis of serum cytokine levels in larynx squamous cell carcinoma and dysplasia patients

background: although the imbalance of cytokines in head and neck squamous cell carcinoma (hnscc) is well known, there is scarce data regarding its occurrence during dysplasia, before the malignant transformation. objective: to determine whether laryngeal dysplasia patients show a different cytokine profile than patients with cancer and healthy controls. methods: seventeen newly diagnosed, untreated larynx squamous cell carcinoma (scc) and six laryngeal dysplasia patients as well as 22 healthy controls were analyzed for circulating cytokines. a flowcytometry th1/th2 cytokine array kit was used to quantitatively measure interleukin-2 (il-2), il-4, il-6, il-10, tumor necrosis factor-α (tnf-α) and interferon-γ (ifn-γ) levels. additionally, il-8 levels were determined through elisa. results: il-6, il-8 and il-10 were determined to be statistically increased in scc patients (p