the effects of cyclooxygenase inhibitors on the brain inflammatory response following traumatic brain injury in rats
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abstract
objective(s) cytokines such as il-1β are involved in inflammatory responses. this study evaluated the role of two different kinds of drugs (ibuprofen and celecoxib) on brain il-10 and il-1β after traumatic brain injury (tbi) in male rats. materials and methods rats were assigned into 6 groups: intact, sham, tbi, and treated rats with vehicle, celecoxib or iboprophen. cytokine concentrations were quantified by elisa kits. results groups showed no significant difference in brain il-10 either after tbi induction or after treatment with ibuprofen or celecoxib. serum il-10 in vehicle or ibuprofen treated animals was lower than in sham groups (p< 0.01). brain il-1β decreased after treatment by ibuprofen or celecoxib (p< 0.001). there was no statistical difference in serum il-1β in tbi and intact. serum il-1β significantly decreased in rats that received celecoxib compared to tbi group (p< 0.01). conclusion based on our study il-1β can decrease through both cyclooxygenase 1 (cox-1) and cox-2 pathway but serum il-1β can decrease only by cox-2 pathway.
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Journal title:
iranian journal of basic medical sciencesجلد ۱۵، شماره ۵، صفحات ۱۱۰۲-۱۱۰۵
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