antioxidant effects of proanthocyanidin from grape seed on hepatic tissue injury in diabetic rats

objective(s):diabetes plays an important role in the induction of the liver injury. grape seed proanthocyanidin (gsp) have a wide range of medicinal properties against oxidative stress. in this study we evaluated antioxidant effects of gsp on liver in streptozotocin-induced diabetic rats. materials and methods: thirty male sprague–dawley rats were divided into three groups: control, untreated diabetic and diabetic rats treated with gsp. diabetes was induced in rats by intraperitoneal injection of streptozotocin (50 mg/kg). gsp were administered via oral gavage (200 mg/kg) for 4 weeks. results: gsp produced significant hepatoprotective effects by decreasing activities of serum aminotransferases and alkaline phosphatase, and decreasing liver malondialdehyde and bilirubin (p<0.05) levels. it increased liver superoxide dismutase, catalase and glutathione peroxidase activities and albumin level (p<0.05). administration of gsp significantly ameliorated structural changes induced in liver of diabetic rats. conclusion: gsp have protective effects against hepatic tissue injury due to antioxidant properties.