the effect of intrathecal delivery of bone marrow stromal cells on hippocampal neurons in rat model of alzheimer’s disease

objective(s): intracerebral injection of bone marrow stromal cells (bmscs) is being investigated as a therapeutic tool to prevent alzheimer's disease (ad). our aim was to investigate the effects of bmscs by intrathecal injection in ad rat model. materials and methods: bmscs were obtained from the bone marrow of wistar rat and transplanted into ad rat model via intrathecal injection. the rat model had received an injection of β amyloid into the hippocampus for histological and immunohistochemical studies. results: histological examination of the brains in transplanted rats compared to controls demonstrated the migration of brdu-labeled bmscs from the site of delivery, confirmed the differentiation of bmscs transplanted cells into the cholinergic neurons, and increased number of healthy and decreased number of dark neurons. conclusion: our results showed that bmscs intratechal administration could be a promising method for treatment ofalzheimer’s disease in rat model.