comparison of 25-hydroxyvitamin d and calcium levels between polycystic ovarian syndrome and normal women

background: given the relationship of vitamin d deficiency with insulin resistance syndrome as the component of polycystic ovary syndrome (pcos), the main aim of this study was to compare serum level of 25- hydroxyvitamin d [25(oh)d] between pcos patients and normal individuals. materials and methods: a cross sectional study was conducted to compare 25(oh)d level between117 normal and 125 untreated pcos cases at our clinic in arash hospital, tehran, iran, during 2011-2012. the obtained levels of 25(oh)d were classified as follows: lower than 25 nmol/ml as severe deficiency, between 25-49.9 nmol/ml as deficiency, 50-74.9 nmol/ml as insufficiency, and above 75 nmol/ml asnormal. in addition, endocrine and metabolic variables were evaluated. results: among pcos patients, our findings shows 3(2.4%) normal, 7(5.6%) with insufficiency, 33(26.4%) with deficiency and 82(65.6%) with severe deficiency, whereas in normal participants, 5(4.3%) normal, 4(3.4%) with insufficiency, 28(23.9%) with deficiency and 80(68.4%) with severe deficiency. comparison of 25(oh)d level between two main groups showed no significant differences (p= 0.65). also, the calcium and 25(oh)d levels had no significant differences in patients with overweight (p=0.22) and insulin resistance (p=0.64). but we also found a relationship between 25(oh)d level and metabolic syndrome (p=0.01). furthermore, there was a correlation between 25(oh)d and body mass index (bmi) in control group (p=0.01), while the c-reactive protein (crp) level was predominantly higher in pcos group (p<0.001). conclusion: although the difference of 25(oh)d level between pcos and healthy women is not significant, the high prevalence of 25(oh)d deficiency is a real alarm for public health care system and may influence our results.