development of sm-153 chitosan for radiosynovectomy

Authors

ali bahrami-samani

amir reza jalilian

hassan yousefnia

mehdi akhlaghi

mohammad mazidi

abstract

introduction: developing new radiosynovectomy agents is of great importance due to the aging of human populations around the world and increasing the incidence of inflammatory diseases. in this work, sm-153 chitosan agent was developed for the first time in our country and preparation and quality control of the compound is described. methods: sm-153 chloride was obtained by thermal neutron flux (4-5 × 1013 n.cm-2.s-1) of natural sm2o3 sample, dissolved in acidic media. 153sm-samarium chloride (370 mbq) was used in preparation of 153sm-chitosan complex followed by quality control using meoh: h2o: acetic acid (4: 4: 2) as mobile phase. the complex stability and viscosity were checked in the final solution up to 2 days. the complex solution and 153sm3+ (80 µci/100 µl) were injected intra-articularly into male rat knee joint followed by scarification studies 6 d post injection. results: sm-153 chitosan was prepared successfully with high radiochemical purity (>99%, itlc) at room temperature after 10-30 min followed by autoclave sterilization. the complex was stable at room temperature and 37ºc up to 2 days. no significant leakage of dose from injection site and its distribution in organs were observed up to 6 days for 153sm-chitosan. conclusion: approximately, more than 90% of injected dose remained in injection site after 6d. the complex is a dedicated agent for radiosynovectomy. the experience from this study would lead to the development of more sophisticated radiosynovectomy radiopharmaceutcals for human use in the country.

Upgrade to premium to download articles

Sign up to access the full text

Already have an account?login

similar resources

Development of Sm-153 chitosan for radiosynovectomy

  Introduction: Developing new radiosynovectomy agents is of great importance due to the aging of human populations around the world and increasing the incidence of inflammatory diseases. In this work, Sm-153 chitosan agent was developed for the first time in our country and preparation and quality control of the compound is described. Methods: Sm-153 chloride was ob...

full text

Development of 177Lu-phytate Complex for Radiosynovectomy

Objective(s): In this work a new possible agent for radiosynovectomy has been targeted for articular pain palliation. Materials and Methods: Lu-177 of 2.6-3 GBq/mg specific activity was obtained by irradiation of natural Lu2O3 sample with thermal neutron flux of 4 × 1013 n.cm-2.s-1. The product was converted into chloride form which was further used for labeling of 177Lu-phytate complex and che...

full text

Preparation and quality control of 177Lu-chitosan for radiosynovectomy

Introduction: Rheumatoid arthritis (RA) is the most common autoimmune disease, leading to the destruction of the joints and causing pain, disability, and immobility in the patients. Radiosynovectomy (RSV) has been applied as an effective treatment for the patients with resistant synovitis after failure of long-term pharmacotherapy and intra-articular steroid injection for more than 50 years. Se...

full text

Preparation and quality control of Lu-chitosan for radiosynovectomy

Introduction: Rheumatoid arthritis (RA) is the most common autoimmune disease, leading to the destruction of the joints and causing pain, disability, and immobility in the patients. Radiosynovectomy (RSV) has been applied as an effective treatment for the patients with resistant synovitis after failure of long-term pharmacotherapy and intra-articular steroid injection for more than 50 years. Se...

full text

Development of 177Lu-phytate Complex for Radiosynovectomy

OBJECTIVE(S) In this work a new possible agent for radiosynovectomy has been targeted for articular pain palliation. MATERIALS AND METHODS Lu-177 of 2.6-3 GBq/mg specific activity was obtained by irradiation of natural Lu2O3 sample with thermal neutron flux of 4 × 10(13) n.cm(-2).s(-1). The product was converted into chloride form which was further used for labeling of (177)Lu-phytate complex...

full text

The influence of Sm-153 therapy on bone marrow function

AIM OF THE STUDY Studies about possible risks connected with β-emitterradiotherapy concentrate mainly on potential myelotoxicity. Results of previously published analysis based on white blood cells (WBC) and platelet (PLT) counts - before and after radionuclide treatment - are quite varied. The aim of our study was to present the greatest possible impact of Samarium-153 on bone marrow function ...

full text

My Resources

Save resource for easier access later


Journal title:
iranian journal of nuclear medicine

Publisher: tehran university of medical sciences

ISSN 1681-2824

volume 18

issue 1 2010

Keywords
[ ' c h i t o s a n ' , ' r a d i o s y n o v e c t o m y ' , ' s a m a r i u m ' , 1 5 3 , ' b i o d i s t r i b u t i o n ' ]

Hosted on Doprax cloud platform doprax.com

copyright © 2015-2023