preparation of [111in]-bleomycin radiopharmaceutical [persian]
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abstract
in this study, the preparation of 111in-bleomycin complex was optimized for temperature, time, concentration and ph during several experiments. the results showed that by the addition of bleomycin to 111in-incl3 sample (dried under flow of n2) and heating the mixture up to 90-100°c the radiopharmaceutical can be obtained in 99.5% yield and a specific activity of 1.745 ci/mmol. the final sample was injected into fibrosarcoma-bearing mice via their tail vein. satisfactory preliminary spect images were acquired between 2-4 hours post-injection showing suitable accumulation in fibrosarcoma tumors.
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Preparation of [111In]-Bleomycin radiopharmaceutical [Persian]
In this study, the preparation of 111In-Bleomycin complex was optimized for temperature, time, concentration and pH during several experiments. The results showed that by the addition of bleomycin to 111In-InCl3 sample (dried under flow of N2) and heating the mixture up to 90-100°C the radiopharmaceutical can be obtained in 99.5% yield and a specific activity of 1.745 Ci/mmol. The final s...
full textAssessment the Effect of Kidney Internal Structure on Gamma Absorbed Dose of Radiopharmaceutical 111In-DTPA
Large quantities of radiopharmaceuticals prescribed for treatment and diagnosis are excreted through kidney. Therefore, radiation unwanted dose is created in kidney. As a result, exact calculation of prescribed radiopharmaceuticals amount is important. Monte Carlo method is used for simulation of radiation transport in body due to random nature of radiation. In this research, for the first time...
full textAssessment the Effect of Kidney Internal Structure on Gamma Absorbed Dose of Radiopharmaceutical 111In-DTPA
Large quantities of radiopharmaceuticals prescribed for treatment and diagnosis are excreted through kidney. Therefore, radiation unwanted dose is created in kidney. As a result, exact calculation of prescribed radiopharmaceuticals amount is important. Monte Carlo method is used for simulation of radiation transport in body due to random nature of radiation. In this research, for the first time...
full textTechnetium-99m radiopharmaceutical preparation problems: 12 years of experience.
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full textDose from syringe procedures during technetium-99m radiopharmaceutical preparation.
UNLABELLED We examined the dose from 99mTc contained in syringes and shielded vials to assess in detail the dose burdens in a central pharmacy. METHODS Absorbed-dose rates at the end of the plunger of a shielded syringe, when 99mTc is contained either in the syringe or in a shielded vial from which the activity would be drawn, were measured with CaF2 dosimeters. The dose rates also were calcu...
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Journal title:
iranian journal of nuclear medicinePublisher: tehran university of medical sciences
ISSN 1681-2824
volume 13
issue 1 2004
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