indium-111 maltolate complex as a cell labeling agent for spect imaging
Authors
abstract
introduction: due to the cell labeling potentials of various metal-maltol complexes, the idea of developing a possible cell labeling imaging agent using single photon emission computed chromatography (spect) with[111in]-maltolate complex has been investigated. methods: [111in] labeled 3-hydroxy-2-methyl-4h-pyran-4-onate ([111in]-maltolate) was prepared using freshly prepared [111in]incl3 and 3-hydroxy-2-methyl-4h-pyran-4-onate in a sodium salt form in 25 min at 45°c. stability of the complex was checked in final formulation and human serum for 48 h. the partition coefficient was calculated for the compound followed by biodistribution and imaging studies. [111in]-maltolate was successively used in the radiolabeling of red blood cells for diagnostic studies. results: the complex was prepared successfully (radiochemical purity: >98% itlc, >98% hplc, specific activity: 15-17 gbq/mmol, log p=0.278). the complex is mostly washed out from the circulation through kidneys in 24h. the cell labeling efficacy was significant at the time of experiment. conclusion: [111in]-maltolate can be an interesting cell imaging agent due to stability and cell avidity of metal maltol complexes, however, further biodistribution studies in various cells as well as diagnostic protocols is necessary.
similar resources
Indium-111 maltolate complex as a cell labeling agent for SPECT imaging
Introduction: Due to the cell labeling potentials of various metal-maltol complexes, the idea of developing a possible cell labeling imaging agent using single photon emission computed chromatography (SPECT) with[111In]-maltolate complex has been investigated. Methods: [111In] labeled 3-hydroxy-2-methyl-4H-pyran-4-onate ([111In]-maltolate) was prepared using f...
full textIndium-111 maltolate complex as a cell labeling agent for SPECT imaging
Introduction: Due to the cell labeling potentials of various metal-maltol complexes, the idea of developing a possible cell labeling imaging agent using single photon emission computed chromatography (SPECT) with [In]-maltolate complex has been investigated. Methods: [In] labeled 3-hydroxy-2-methyl-4H-pyran-4-onate ([In]-maltolate) was prepared using freshly prepared [In]InCl3 and 3-hydroxy-2-m...
full textDevelopment of Ga-67 Maltolate Complex as an Imaging Agent
Due to the antitumor activity of Gallium MAL complex, as well as recent findings on new targeted biomolecules in malignant cells through this complex, the development of radiolabeled gallium complex for future imaging studies was targeted. Ga-67 labeled 3-hydroxy-2-methyl-4H-pyran-4-onate (Ga-67 MAL) was prepared using freshly prepared Ga-67 chloride and 3-hydroxy-2-methyl-4H-pyran-4-onate in a...
full textDevelopment of Ga-67 Maltolate Complex as an Imaging Agent
Due to the antitumor activity of Gallium MAL complex, as well as recent findings on new targeted biomolecules in malignant cells through this complex, the development of radiolabeled gallium complex for future imaging studies was targeted. Ga-67 labeled 3-hydroxy-2-methyl-4H-pyran-4-onate (Ga-67 MAL) was prepared using freshly prepared Ga-67 chloride and 3-hydroxy-2-methyl-4H-pyran-4-onate in a...
full textdevelopment of ga-67 maltolate complex as an imaging agent
due to the antitumor activity of gallium mal complex, as well as recent findings on new targeted biomolecules in malignant cells through this complex, the development of radiolabeled gallium complex for future imaging studies was targeted. ga-67 labeled 3-hydroxy-2-methyl-4h-pyran-4-onate (ga-67 mal) was prepared using freshly prepared ga-67 chloride and 3-hydroxy-2-methyl-4h-pyran-4-onate in a...
full textDevelopment of Ga-67 Maltolate Complex as an Imaging Agent
Due to the antitumor activity of Gallium MAL complex, as well as recent findings on new targeted biomolecules in malignant cells through this complex, the development of radiolabeled gallium complex for future imaging studies was targeted. Ga-67 labeled 3-hydroxy-2-methyl-4H-pyran-4-onate (Ga-67 MAL) was prepared using freshly prepared Ga-67 chloride and 3-hydroxy-2-methyl-4H-pyran-4-onate in a...
full textMy Resources
Save resource for easier access later
Journal title:
iranian journal of nuclear medicinePublisher: tehran university of medical sciences
ISSN 1681-2824
volume 20
issue 2 2012
Hosted on Doprax cloud platform doprax.com
copyright © 2015-2023