cd8+ t lymphocyte subsets in bladder tumor draining lymph nodes
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CD8+ T Lymphocyte Subsets in Bladder Tumor Draining Lymph Nodes
Background: Cytotoxic CD8+ T cells, as essential parts of the adaptive immune system, play pivotal roles in anti-tumor immune responses. It is well documented that cytokine expression profiles and activation status of these cells during anti-tumor immune responses affect the outcome of host-tumor interaction. Objective: To investigate the percentages of CD8+ lymphocytes and their subsets in...
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full textIncomplete differentiation of antigen-specific CD8 T cells in tumor-draining lymph nodes.
CD8 T cells lacking effector activity have been recovered from lymphoid organs of mice and patients with progressing tumors. We explored the basis for lack of effector activity in tumor-bearing mice by evaluating Ag presentation and CD8 T cell function in lymphoid organs over the course of tumor outgrowth. Early after tumor injection, cross-presentation by bone marrow-derived APC was necessary ...
full textQuantitative, Architectural Analysis of Immune Cell Subsets in Tumor-Draining Lymph Nodes from Breast Cancer Patients and Healthy Lymph Nodes
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Background: NK (natural killer) and NKT (natural killer T) cells, as components of innate immune system, play a crucial role in tumor progression and dissemination. Objective: To investigate the percentages of NK cells, NKT cells, iNKT (invariant natural killer T) cells, total T lymphocytes as well as activated T lymphocytes, in tumor draining lymph nodes (TDLN...
full textil-17 and il-4 producing cd8+ t cells in tumor draining lymph nodes of breast cancer patients: positive association with tumor progression
background: cd8+ cytotoxic t lymphocytes have been recently divided based on their cytokine expression profile. objective: to evaluate the percentages of cd8+ lymphocytes and their effector subsets including tc1, tc2 and tc17 in the tumor draining lymph nodes (tdlns) of patients with breast cancer. methods: single cell suspensions were obtained from tdlns of 42 patients with breast cancer. stai...
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Journal title:
iranian journal of immunologyجلد ۱۳، شماره ۴، صفحات ۲۳۷-۲۴۸
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