effects of combining methylprednisolone with magnesium sulfate on neuropathic pain and functional recovery following spinal cord injury in male rats.

Authors

leila farsi brain and spinal cord injury research center, neuroscience institute, tehran university of medical sciences, tehran, iran.

maryam naghib zadeh electrophysiology research center, neuroscience institute, tehran university of medical sciences, tehran, iran.

khashayar afshari electrophysiology research center, neuroscience institute, tehran university of medical sciences, tehran, iran.

abbas norouzi-javidan brain and spinal cord injury research center, neuroscience institute, tehran university of medical sciences, tehran, iran.

abstract

methylprednisolone (mp) has been widely used as a standard therapeutic agent for the treatment of spinal cord injury (sci). because of its controversial useful effects, the combination of mp and other pharmacological agents to enhance neuroprotective effects is desirable. magnesium sulfate (mgso4) has been shown to have neuroprotective and antihyperalgesic effects. in the present study, we sought to determine the effect of combining mp and mgso4, on neuropathic pain and functional recovery following spinal cord injury (sci) in male rats. a total of 48 adult male rats (weight 300-350 g) were used. after laminectomy, complete sci was achieved by compression of the spinal cord for one minute with aneurysm clips. single doses of magnesium sulfate (mgso4), (600 mg/kg), methylprednisolone (mp), (30 mg/kg) or combining mgso4 and mp were injected intraperitoneally. prior to surgery and during four weeks of study tail flick latency (tfl) and bbb (basso-beattie-bresnahan) score and the acetone drop test were evaluated. in mean values of bbb score, a significant difference was observed in sci+veh compared with other groups (p<0.05). mean tfl also was significantly higher in sci+veh compared with other groups (p<0.05). mean acetone drop test score and weight were significantly different in mgso4, mp and combining mgso4 and mp  treated groups compared with sci+veh group (p<0.05). these findings revealed that mp, mgso4 and combining mgso4 and mp treatment can attenuate neuropathic pains following sci in rats include: thermal hyperalgesia and cold allodynia. they also can yield better improvement in motor function and decrease weight loss after sci in rats compared with the control group.

Upgrade to premium to download articles

Sign up to access the full text

Already have an account?login

similar resources

Effects of combining methylprednisolone with magnesium sulfate on neuropathic pain and functional recovery following spinal cord injury in male rats.

Methylprednisolone (MP) has been widely used as a standard therapeutic agent for the treatment of spinal cord injury (SCI). Because of its controversial useful effects, the combination of MP and other pharmacological agents to enhance neuroprotective effects is desirable. Magnesium sulfate (MgSO4) has been shown to have neuroprotective and antihyperalgesic effects. In the present study, we soug...

full text

Effect of coenzyme Q10 on neuropathic pain threshold resulting from spinal cord injury in male rats

Introduction: Coenzyme Q10 is a powerful antioxidant that has the ability to reduce the damage caused by oxidative stress and is predominantly found in the inner mitochondrial membrane. This study was conducted to determine the effect of coenzyme Q10 on neuropathic pain in an animal model of spinal cord injury. Methods: In order to induce neuropathic pain, thoracic segments of the spinal cor...

full text

Effects of the combination of methylprednisolone with aminoguanidine on functional recovery in rats following spinal cord injury

Methylprednisolone (MP), a synthetic glucocorticoid, has been widely used as a standard therapeutic agent for the treatment of spinal cord injury (SCI). The combination of MP and other pharmacological agents aimed at enhancing functional recovery is desirable as the beneficial effects of MP are controversial, due to a variety of side-effects. Aminoguanidine (AG), a small water-soluble compound,...

full text

Analgesic Effect of Bumetanide on Neuropathic Pain in Patients With Spinal Cord Injury

Objectives: The current study evaluated the analgesic effects of bumetanide as an adjunctive in the management of neuropathic pain following spinal cord injury (SCI). The peripheral expression of Na-K-Cl cotransporter-1 (NKCC1) and K-Cl cotransporter-2 (KCC2) genes in polymorphonuclear lymphocytes (PMLs) was assessed as a possible biomarker indicating central mechanisms underlying the observed ...

full text

the effect of aqueous extract of garlic on formalin-induced pain in male rats

چکیده اثر عصاره آبی سیر بر درد ناشی از آزمون فرمالین در موش صحرایی نر به کوشش نرگس اسکندری روزبهانی زمینه و هدف: گیاه سیر از خانواده لیلیاسه و گونهallium sativum بومی آسیای میانه بوده و از دوران ،باستان تاکنون به خواص درمانی متفاوت آن مثل: کاهندگی قندخون، کلسترول خون، فشار خون، اثرات مفیدآن بر دستگاه قلبی عروقی و بیماریهای انعقادی خون، اثرات آنتی اکسیداتیو، درمان بیماریهای تنفسی وگوارشی، ا...

15 صفحه اول

Influence of Sexuality in Functional Recovery after Spinal Cord Injury in rats

  Background: Spinal cord injury (SCI) is a major clinical condition and research is commonly done to find suitable treatment options. However, there are some degrees of spontaneous recovery after SCI and gender is said to be a contributing factor in recovery, but this is controversial. This study was done to compare the effects of sexual dimorphism on spontaneous recovery after spinal cord inj...

full text

My Resources

Save resource for easier access later


Journal title:
acta medica iranica

جلد ۵۳، شماره ۳، صفحات ۱۴۹-۱۵۷

Hosted on Doprax cloud platform doprax.com

copyright © 2015-2023