muscle biopsy
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abstract
muscle biopsy has been used for a long time for diagnosis of muscular, nerurogenic and systemic disorders with muscle involvement, because only very few of these disorders show sufficient specific clinical features for definite diagnosis. since the presence of difficulties in the screening of numerous genes, muscle biopsy could be a time and cost effective procedure for solving the diagnostic problems. the aim of this article is to mention the importance of muscle tissue in the evaluation of primary and secondary muscle diseases, special consideration of how to biopsy, handling the specimen and performing the special staining, and the microscopic findings in order to have better interpretation results.
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Muscle Biopsy
Muscle biopsy has been used for a long time for diagnosis of muscular, nerurogenic and systemic disorders with muscle involvement, because only very few of these disorders show sufficient specific clinical features for definite diagnosis. Since the presence of difficulties in the screening of numerous genes, muscle biopsy could be a time and cost effective procedure for solving the diagnostic p...
full textMetabolic Exploration of Muscle Biopsy
It has been well established that in several chronic diseases such as in chronic obstructive pulmonary disease (COPD), diabetes, cancer or congestive heart failure patients, next to central dysfunctions, the patients develop some systemic consequences that can lead to peripheral muscle dysfunction. Some important clinical implications such as reduced exercise capacity, reduced quality of life a...
full textMuscle biopsy in Pompe disease.
UNLABELLED Pompe disease (PD) can be diagnosed by measuring alpha-glucosidase levels or by identifying mutations in the gene enzyme. Muscle biopsies can aid diagnosis in doubtful cases. METHODS A review of muscle biopsy from 19 cases of PD (infantile, 6 cases; childhood, 4 cases; and juvenile/adult, 9 cases). RESULTS Vacuoles with or without glycogen storage were found in 18 cases. All case...
full textToxic myopathies: muscle biopsy features.
Several drugs and toxic substances can cause muscular abnormalities and are frequent causes of acquired myopathies. We present a series of 32 patients, predominance of young adult patients, diagnosed with toxic myopathy. The most common substances inducing myopathy were corticosteroids (56.2%) followed by the propoxyphene, neuroleptics, zidovudine and drug-induced hypokalemia. The investigation...
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Journal title:
iranian journal of pathologyPublisher: iranian society of pathology
ISSN 1735-5303
volume 7
issue 2 2012
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