potential drug-drug interactions in post-ccu of a teaching hospital

Authors

mohammad haji aghajani department of cardiology, imam husain educational hospital, shahid beheshti university of medical sciences, tehran, iran.

mohammad sistanizad 1- department of clinical pharmacy, faculty of pharmacy, shahid beheshti university of medical sciences, tehran, iran. 2- imam husain educational hospital, shahid beheshti university of medical sciences, tehran, iran. 3- pharmaceutical sciences research center, shahid beheshti university of medical sciences, tehran, iran. 2-emam hossein hospital, shahid beheshti medical university, tehran, iran.

mohammad abbasinazari 1- department of clinical pharmacy, faculty of pharmacy, shahid beheshti university of medical sciences, tehran, iran. 2-anesthesiology researchcenter-shahidbeheshtiuniversity of medical sciences, tehran, iran. 2- anesthesiology research center, shahid beheshti university of medical sciences, tehran, iran.

mahdieh abiar ghamsari department of clinical pharmacy, faculty of pharmacy, shahid beheshti university of medical sciences, tehran, iran.

abstract

drug-drug interactions (ddis) can lead to increased toxicity or reduction in therapeutic efficacy. this study was designed to assess the incidence of potential drug interactions (pdi) and rank their clinical value in post coronary care unit (post-ccu) of a teaching hospital in tehran, iran.in this prospective study, three pharmacists with supervision of a clinical pharmacist actively gathered necessary information for detection of ddis. data were tabulated according to the combinations of drugs in treatment chart. verification of potential drug interactions was carried out using the online lexi-interact™ 2011.a total of 203 patients (113 males and 90 females) were enrolled in the study. the mean age of patients was 61 ± 12.55 years (range = 26-93). a total of 90 drugs were prescribed to 203 patients and most prescribed drugs were atorvastatin, clopidogrel and metoprolol. mean of drugs was 11.22 per patient. a total of 3166 potential drug interactions have been identified by lexi-interact™, 149 (4.71%) and 55 (1.73%) of which were categorized as d and x, respectively. the most serious interactions were clopidogrel+omeprazole and metoprolol+salbutamol.drug interactions leading to serious adverse effects are to be cautiously watched for when multiple drugs are used simultaneously. in settings with multiple drug use attendance of a pharmacist or clinical pharmacist, taking the responsibility for monitoring drug interactions and notifying the physician about potential problems could decrease the harm in patient and increase the patient safety.

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Journal title:
the iranian journal of pharmaceutical research

جلد ۱۲، شماره ۱، صفحات ۲۴۳-۲۴۸

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