the effect of green tea extract on reproductive improvement in estradiol valerate-induced polycystic ovary polycystic ovarian syndrome in rat

polycystic ovary syndrome (pcos) is a reproductive and metabolic disorder in which thelevel of oxidative elements in blood rises. green tea is a potent antioxidant since it containscatechins. in this study, the effect of hydro-alcoholic green tea extract on pcos rats was examined.for pcos induction, 96 mature wistar rats were given estradiol valerate. after 60 days, therats were divided into four groups including pcos group and three experimental groups, whichwere given 50, 100 and 200 mg/kg bw green tea extract 10 days, intraperitoneally. the serumconcentration level of fsh, lh, testosterone and insulin were measured using elisa method,while the serum concentration level of glucose was measured using glucose oxidase methods.insulin resistance was calculated using homa-ir formulation. the data were analyzed usingthe one-way anova method considering p<005/ level of significance.there were a significant reduction in lh serum level, body and ovarian weight between thegreen tea extract treated-groups compare to pcos. moreover, a significant reduction in insulinresistance index was seen in the treatment groups related to pcos. histomorphometric studiesalso showed the significant changes in the number of follicles and theca layer thickness.these changes demonstrated a marked improvement in the symptoms of pcos which maybe due to green tea effects on oxidative stress pathways. green tea can be considered as apotentially effective drug for treatment of pcos, insulin resistance and type ii diabetes.