nitroimidazoles vii [i]. syntheses, antibacterial and antifungal act i v i t i e s of 4 - s u b s t i t u t e d - 2 - twiazolylhydrazones

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reaction of readily available 2-formyl -1-methyl-5-nitroimidazole (1) with 4-substituted-2-hydrazinothiazoles (2) afforded 2-formyl-l-methyl-5- nitroimidazole 4-substituted -2- thiazolylhydrazones (3). reaction of thiochromitn-4-one (4) with thiosemicarbazide gave thiochroman-4- one thiosemicarbazone (5). reaction of compound 5 with clc- haloaldehyde or ketones y ielded thiochroman--#-one 4-substituted-2-thiazolylhydrozones(6). the antibacterial and antifungal activities of compounds 3 and 6 against a number of microorganisms were determined

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Journal title:
journal of sciences islamic republic of iran

جلد ۱، شماره ۲، صفحات ۰-۰

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