comparison of c-kit expression between primary and metastatic melanoma of skin and mucosa

Authors

fatemeh sari aslani skin molecular research center, shiraz university of medical sciences, shiraz, iran.سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (shiraz university of medical sciences)

bita geramizadeh transplant research center, medical school, shiraz university of medical sciences. shiraz, iran.سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (shiraz university of medical sciences)

amir reza dehghanian trauma research center, medical school shiraz university of medical sciences, shiraz, iran.سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (shiraz university of medical sciences)

abstract

background: melanoma causes the greatest morbidity and mortality of all skin cancers. mucosal melanoma is a rare but highly aggressive neoplasm. according to previous studies the prevalence of kit mutations in acrallentiginous and mucosal melanomas is relatively low (less than 15–20%), but it can have profound therapeutic implications for localized high risk or metastatic diseases. our goal was to evaluate c-kit expression in different types of primary and metastatic melanoma to discriminate potential candidates for targeted therapy.   methods : we designed a cross-sectional study and selected 50 cases of malignant melanoma (primary, metastatic cutaneous, and mucosal) from the affiliated hospitals of shiraz university of medical sciences in the period of 2008 to 2012. immunohistochemistry for kit expression was performed. multistage sampling method was selected for sampling and chi-square test was used for statistical analysis.   results : in our study, male to female ratio was 1.77. the male sex was correlated with higher tumor stage (p< 0.05). 62% (n=31) of cases showed at least 5% of kit-positive cells, consist of 18% (n=9) with 5–50%, 16% (n=8) with 51–95%, and 28% (n=14) of cases showed more than 95% of cells expressing kit. but in 38% (n=19) of cases kit expression was less than 5% of positive cells. tumor stage was positively correlated with tumor cell immunoreactivity and intensity (p< 0.05). metastatic melanoma showed lower percentage (43%) of positivity. intensity of staining and percentage of positive cells were positively correlated (p< 0.001).   conclusion : in primary melanomas, significant kit expression was found by immunohistochemistry, which may be useful to screen the patients for advising to kit mutation analysis and targeted therapy.

Upgrade to premium to download articles

Sign up to access the full text

Already have an account?login

similar resources

Comparison of c-Kit expression between primary and metastatic melanoma of skin and mucosa

  Background: Melanoma causes the greatest morbidity and mortality of all skin cancers. Mucosal melanoma is a rare but highly aggressive neoplasm. According to previous studies the prevalence of KIT mutations in acrallentiginous and mucosal melanomas is relatively low (less than 15–20%), but it can have profound therapeutic implications for localized high risk or metastatic diseases. Our goal w...

full text

Comparison of c-Kit expression between primary and metastatic melanoma of skin and mucosa

BACKGROUND Melanoma causes the greatest morbidity and mortality of all skin cancers. Mucosal melanoma is a rare but highly aggressive neoplasm. According to previous studies the prevalence of KIT mutations in acral lentiginous and mucosal melanomas is relatively low (less than 15-20%), but it can have profound therapeutic implications for localized high risk or metastatic diseases. Our goal was...

full text

assessment of deep word knowledge in elementary and advanced iranian efl learners: a comparison of selective and productive wat tasks

testing plays a vital role in any language teaching program. it allows teachers and stakeholders, including program administrators, parents, admissions officers and prospective employers to be assured that the learners are progressing according to an accepted standard (douglas, 2010). the problems currently facing language testers have both practical and theoretical implications but the first i...

My Resources

Save resource for easier access later


Journal title:
medical journal of islamic republic of iran

جلد ۲۹، شماره ۱، صفحات ۳۵۳-۳۵۸

Hosted on Doprax cloud platform doprax.com

copyright © 2015-2023