n-glucosides: new phase-ii metabolites of two barbiturates
Authors
abstract
the new phase-ii n-glucoside metabolites of butobarbitone and pentobarbitone are identified and quantified in human urine after single doses of these drugs. the identification and quantification of these metabolites were carried out by mass spectroscopy technique (accurate mass measurement and high voltage scanning). it was found that the butobarbitone n-glucoside comprised 26% of the dose with tl/2= 44h, while the pentobarbitone n-glucoside was 43% with t1/2= 40h.
similar resources
N-GLUCOSIDES: NEW PHASE-II METABOLITES OF TWO BARBITURATES
The new phase-II N-glucoside metabolites of butobarbitone and pentobarbitone are identified and quantified in human urine after single doses of these drugs. The identification and quantification of these metabolites were carried out by mass spectroscopy technique (accurate mass measurement and high voltage scanning). It was found that the butobarbitone N-glucoside comprised 26% of the dos...
full textSYNTHESIS OF NEW PHASE- 1 METABOLITES OF TWO BARBITURATES
The new 4'- hydroxy and 3'- aldehyde phase- 1 metabolites of butobarbitone and pentobarbitone are fully synthesized for the first time. These metabolites were used to idenfity and quantify the natural metabolites in human urine after single and multiple doses of these drugs. The synthesized metobolites have spectral characterizations (IR, NMR, U.V. and mass spectroscopy) consisted with the ...
full textsynthesis of platinum nanostructures in two phase system
چکیده پلاتین، فلزی نجیب، پایدار و گران قیمت با خاصیت کاتالیزوری زیاد است که کاربرد های صنعتی فراوانی دارد. کمپلکس های پلاتین(ii) به عنوان دارو های ضد سرطان شناخته شدند و در شیمی درمانی بیماران سرطانی کاربرد دارند. خاصیت کاتالیزوری و عملکرد گزینشی پلاتین مستقیماً به اندازه و- شکل ماده ی پلاتینی بستگی دارد. بعضی از نانو ذرات فلزی در سطح مشترک مایع- مایع سنتز شده اند، اما نانو ساختار های پلاتین ب...
Two new phenolic glucosides from Lagerstroemia speciosa.
Two new phenolic glucosides, 1-O-benzyl-6-O-E-caffeoyl-β-d-glucopyranoside and 1-O-(7S,8R)-guaiacylglycerol-(6-O-E-caffeoyl)-β-d-glucopyranoside, were isolated from the aerial parts of Lagerstroemia speciosa, along with ten known compounds. The structures of the isolated compounds were determined based on 1D- and 2D-NMR, Q-TOF MS and optical rotation spectroscopic data. All of the compounds sho...
full textIdentification of Phase I & Phase II Metabolites of Maca Constituents
Maca (Lepidium meyenii Walpers) is a plant cultivated in central Peru, and its root is a common active ingredient in the botanical dietary supplements for its effects on a variety of health issues such as sexual dysfunction, anemia, and cancer. The plant contains compounds that have cytotoxic and antioxidant activities, but information on the metabolism of the bioactive compounds is limited. Th...
full textTwo new cyanogenic glucosides from the leaves of Hydrangea macrophylla.
Chemical investigation of the ethanol extract of the aerial parts of Hydrangea macrophylla collected in the Sichuan Province of China resulted in the isolation of two new cyanogenic glucosides. Their structures were elucidated as [(2R)-2-β-D-glucopyranosyloxy)-2-(3,4-dimethoxy-phenyl)] acetonitrile (1) and {(2R)-2-[α-D-glucopyranosyl(1-->6)β-D-glucopyranosyloxy]-2-(3-hydroxy-4-methoxy-phenyl)}a...
full textMy Resources
Save resource for easier access later
Journal title:
medical journal of islamic republic of iranجلد ۶، شماره ۱، صفحات ۶۳-۶۶
Hosted on Doprax cloud platform doprax.com
copyright © 2015-2023