serum levels of interleukin-27 and interleukin-33 in patients with dermatomyositis and polymyositis compared to healthy control subjects
Authors
abstract
background in some autoimmune diseases such as rheumatoid arthritis (ra), interleukin-27 (il-27) and il-33 levels are increased. these observations suggest that il-27 and il-33 may have a role in the pathogenesis of polymyositis/dermatomyositis (pm/dm). conclusions these data indicate that il-27 might be selectively involved in the pathogenesis of dm and pm. however, il-33 does not appear to be influenced. results the serum levels of il-27 in patients with dm and pm were higher than those of healthy controls. there were no significant differences in serum levels of il-33 in patients with dm and pm compared to the healthy control group. patients and methods twenty patients with dm and nine patients with pm were recruited in this study. twenty-nine healthy controls whose age and gender were matched with the patients were also recruited. serum il-27 and il-33 was measured by the enzyme-linked immunosorbent assay (elisa). objectives the aim of this study was to assess il-27 and il-33 levels in pm/dm patients compared to healthy control subjects.
similar resources
Serum Levels of Interleukin 17 in Patients with Pemphigus and Healthy Subjects
Introduction: Pemphigus is a relatively rare autoimmune bullous disease involving skin and mucous epithelia. The disease occurs as a result of production of auto-antibodies against inter-cellular epithelia especially cadherin and desmoglein. Interleukin 17 (IL-17) is one of the specific cytokines of T helper. IL-17 plays an important role in delayed type reaction and recruits neutrophils and mo...
full textComparison of serum interleukin-8 levels in patients with recurrent aphthous stomatitis and healthy individuals
Comparison of serum interleukin-8 levels in patients with recurrent aphthous stomatitis and healthy individuals Dr. HR. Abdolsamadi* - Dr. Sh. Kasraie** * Assistant Professor of Oral Medicine Dept., Faculty of Dentistry, Hamadan University of Medical Sciences. ** Assistant Professor of Operative Dentistry Dept., Faculty of Dentistry, Hamadan University of Medical Sciences. Background and Aim: R...
full textComparison of Serum Vitamin D and Interleukin-6 Levels in Patients with Preeclampsia and Healthy Pregnant Women
ABSTRACT Background and Objective: Nutritional factors and activation of inflammatory pathways are thought to be involved in pathogenesis of preeclampsia in pregnant women. The present study aimed to compare the serum levels of vitamin D and interleukin-6 in healthy pregnant women with those of preeclampsia ones. &...
full textReduced interleukin-18 levels in BAL specimens from patients with asthma compared to patients with sarcoidosis and healthy control subjects.
STUDY OBJECTIVES To investigate whether differing airway interleukin (IL)-18 levels may be implicated in the pathogenesis of asthma and sarcoidosis. SETTING University teaching hospital. PATIENTS AND METHODS IL-18 levels were measured in BAL fluid and in the supernatant of lipopolysaccharide (LPS)-stimulated alveolar macrophages obtained by BAL from 15 patients with sarcoidosis, 11 patients...
full textLevels of Interleukin 33 and Interleukin 27 in Rheumatoid Arthritis and Osteoarthritis Egyptian patients
Background: Cytokines are important mediators of immune functions in humans and animals. IL-27, an IL-12 family cytokine, exerts a critical role in immune regulation in the context of infection and autoimmunity. IL-33, a newly foundIL-1 family cytokine is involved in joint inflammation in rheumatoid arthritis (RA). So, we aimed to investigate the immunopathological roles of IL-27 and IL-33 in s...
full textUpregulation of Interleukin 21 and Interleukin 21 Receptor in Patients with Dermatomyositis and Polymyositis
BACKGROUND The immunopathologic mechanism underlying dermatomyositis (DM) and polymyositis (PM) remains poorly understood. Many cytokines play a pathogenic role in DM and PM. Interleukin 21 (IL-21) has a pleiotropic effect on inflammation regulation. This study aimed to detect the serum IL-21 level and investigate the expression of IL-21 and IL-21 receptor (IL-21R) in muscle tissues of patients...
full textMy Resources
Save resource for easier access later
Journal title:
gene, cell and tissueجلد ۲، شماره ۴، صفحات ۰-۰
Hosted on Doprax cloud platform doprax.com
copyright © 2015-2023