immunohistochemical analysis of ki-67 expression in oral lichen planus lesions

introdouction: lichen planus is a chronic, relatively common, dermal mucosa disease. the world health organization (who) has introduced lichen planus as a premalignant condition. ki-67 is a protein that can be detected in all active phases of the cell cycle, especially in the g2 and m phases. considering the major role of ki-67 in the regulation of the cell cycle and the fact that it is one of the conditions for pre-malignant potential and epithelial proliferation, the aim of this study was to evaluate ki-67 expression in oral lichen planus (olp) lesions. materials and methods: this study included 32 patients [16 with olp and 16 with no olp and a normal epithelium, which were considered the control group (cg)]. demographic data was extracted from each patient’s file and documented in an information form. immunohistochemistry for ki-67 was conducted using the envision method. p value was significant at <0.05. results: ki-67 staining quality in the olp group was significantly greater than the cg group according to both the mann–whitney test and quantity (p = 0.001). the average percentage of positive cells in the olp group was 13.11, while the average in the cg group was 2.26. ki-67 staining in olps was 87.5% (++) and 62% with a strong degree of staining. age and gender differences were compared using the independent t-test no significant statistical differences were noted between the two groups. conclusion: considering ki-67 is a proliferation marker, the increased expression of ki-67 in the olp group’s epithelium indicates a high proliferation rate in lichen planus lesions.