Prevalence of Premalignant Cervical Lesions in Women With a Long-term Nonprogressor or HIV Controller Phenotype
نویسندگان
چکیده
PHI. Chronic HIV-infected patients with CXCR4-using viruses are described as having faster disease progression compared with patients with CCR5-tropic strains. Our analysis did not support this relation, and we found a greater CD4+-cell increase after initiation of ART in patients harboring CXCR4-using virus, regardless of algorithm choice. Patients with CXCR4-tropic viruses have a greater CD4-cell decrease without ART, and in chronic patients HIV tropism has no impact on immunovirological response. CXCR4-tropic viruses replication is lower than that of CCR5 variants in GALT, and CCR5 viruses are also more prone to infect macrophages especially during PHI. Starting ART during PHI in patients with CXCR4 viruses could help in increasing plasma CD4+ cells by targeting viral replication in peripheral blood, whereas ART has a limited effect on GALT CD4+-cell depletion which occurs mainly due to CCR5 variants. This may explain our findings of a better immunological recovery as measured by plasma CD4+-cell increase. The influence of predicted coreceptor usage on GALT CD4-cell depletion remains unclear. All of the patients had antiretroviral syndrome, and no data are available regarding the association between symptoms and coreceptor usage: this could represent a selection of more pathogenic viruses, usually CXCR4 using. Further studies with phenotypic assays are needed to better evaluate the feasibility of genotypic methods to predict coreceptor usage in the setting of PHI. In conclusion our study remarks an immunological recovery in patients treated during PHI, even if harboring CXCR4-tropic virus; these results encourage treatment during this phase of infection.
منابع مشابه
A pilot study to compare HIV status and cervical and penile pathology among couples attending the urology unit at the University Teaching Hospital Lusaka, Zambia.
BACKGROUND Cancer of the cervix is the most common malignancy in women of childbearing age in Zambia. It is known to be associated with HIV infection and oncogenic strains of HPV. However, there are few studies of penile lesions as a predictor of malignant and premalignant cervical lesions in female partners. OBJECTIVES The aim of the study was to determine the association between men with pe...
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