Centrosome Biogenesis: Centrosomin Sizes Things Up!
نویسندگان
چکیده
Centrosomes are composed of a centriole pair surrounded by a proteinaceous matrix of pericentriolar material that contains protein complexes required for microtubule nucleation and anchoring. Recent work reveals an intriguing link between centrioles and pericentriolar material that is involved in modulating centrosome size.
منابع مشابه
The centrosomin protein is required for centrosome assembly and function during cleavage in Drosophila.
Centrosomin is a 150 kDa centrosomal protein of Drosophila melanogaster. To study the function of Centrosomin in the centrosome, we have recovered mutations that are viable but male and female sterile (cnnmfs). We have shown that these alleles (1, 2, 3, 7, 8 and hk21) induce a maternal effect on early embryogenesis and result in the accumulation of low or undetectable levels of Centrosomin in t...
متن کاملThe centrosomin CM2 domain is a multi-functional binding domain with distinct cell cycle roles
The centrosome serves as the main microtubule-organizing center in metazoan cells, yet despite its functional importance, little is known mechanistically about the structure and organizational principles that dictate protein organization in the centrosome. In particular, the protein-protein interactions that allow for the massive structural transition between the tightly organized interphase ce...
متن کاملThe centrosomal protein centrosomin A and the nuclear protein centrosomin B derive from one gene by post-transcriptional processes involving RNA editing.
The identification of a gene encoding concomitantly a nuclear protein and an intrinsic centrosomal protein further emphasizes the close and presumably developmental relationship between the cell nucleus and the centrosome. Screening of a murine RNA-based cDNA library with an antiserum to a centrosomal protein and rescreening with the insert of an initial clone released two complete cDNAs (1.2 k...
متن کاملJourney to the center of the centrosome.
Little is understood about how the centrosome, a complex organelle and signaling hub consisting of hundreds of components, is assembled. In this issue of Developmental Cell, Conduit et al. (2014) shed light on this issue, showing that modification and recruitment of Centrosomin to the centrosome center creates a dynamic pericentriolar matrix.
متن کاملCentrocortin Cooperates with Centrosomin to Organize Drosophila Embryonic Cleavage Furrows
In the Drosophila early embryo, the centrosome coordinates assembly of cleavage furrows. Currently, the molecular pathway that links the centrosome and the cortical microfilaments is unknown. In centrosomin (cnn) mutants, in which the centriole forms but the centrosome pericentriolar material (PCM) fails to assemble, actin microfilaments are not organized into furrows at the syncytial cortex [6...
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ورودعنوان ژورنال:
- Current Biology
دوره 20 شماره
صفحات -
تاریخ انتشار 2010