Onconeural antibodies with special reference to anti-Yo
نویسندگان
چکیده
..............................................................................................................7 LIST OF PUBLICATIONS.........................................................................................9 ABBREVIATIONS...................................................................................................10 1. THE IMMUNE SYSTEM ..................................................................................11 1.1 Immune system in the central nervous system..................................................................................... 13 1.2 Autoimmunity ......................................................................................................................................... 13 1.2.1 Autoantibodies ............................................................................................................................... 15 1.3 Antibody avidity ..................................................................................................................................... 17 1.4 Tumour immunity .................................................................................................................................. 19 2. ATM AND CCDC104 .......................................................................................24 3. PARANEOPLASTIC NEUROLOGICAL SYNDROMES..................................26 3.1 Paraneoplastic cerebellar degeneration................................................................................................ 32 3.2 Paraneoplastic antibodies and antigens................................................................................................ 33 3.2.1 Yo antibodies ................................................................................................................................. 38 4. THE CDR PROTEINS......................................................................................41 4.1 CDR1 ....................................................................................................................................................... 41 4.2 CDR2 ....................................................................................................................................................... 42 4.3 CDR2L..................................................................................................................................................... 45 1
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