Interaction between effector and memory cd8+ t cells enhances melanoma adoptive immunotherapy
نویسندگان
چکیده
Introduction Our laboratory has previously demonstrated that adoptive cell transfer (ACT) of melanoma-specific memory T cells (TM) results in a more potent local and systemic T cell response than ACT with melanoma-specific effector T cells (TE). However, we have also seen that TM are not more cytotoxic than TEin vitro. We hypothesized that a combination of TE+M ACT would have an additive effect compared to TE and TM ACT alone.
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