Proteins Rule! StanPrusinerPrion Biology and Diseases1999Cold Spring Harbor Laboratory PressCold Spring Harbor, NY710 pp. $125.00

Trade-offs

23. Stent, G.S. (1972). Prematurity and uniqueness in scientific discovery. Sci. Am. 227, 84–93. 24. Mirsky, A.E., and Pollister, A.W. (1946). Chromosin, a desoyribose nucleoprotein complex of the cell nucleus. J. Gen. Physiol. 30, 117–148. 25. Boivin, A. (1947). Directed mutation in colon bacilli, by an inducing principle of desoxyribonucleic nature: Its meaning for the general biochemistry of...

Protein-conducting channels for the translocation of proteins into and across membranes.

Comm with me

NAi may carry out direct silencing not only of RNAs but also of DNA, according to new results from Tom Volpe, Shiv Grewal, Rob Martienssen, and colleagues (Cold Spring Harbor Laboratory (CSHL), Cold Spring Harbor, NY), and Brenda Reinhart and David Bartel (Whitehead Institute, Cambridge, MA). Another group, led by Kazufumi Mochizuki and Martin Gorovsky (University of Rochester, Rochester, NY), ...

Selective membrane recruitment of Rab GTPases.

The Centrality of RNA, Then and Now JamesDarnellRNA. Life's Indispensable Molecule2011Cold Spring Harbor Laboratory PressCold Spring Harbor, NY, USA416 pp. $39.

Today, the critical roles of RNA in information transfer are taken for granted. Most graduate students can recite the basic rubrics of molecular biology; DNA is transcribed to make pre-mRNA, which is then extensively processed in the nucleus to yield mRNA. The mRNA is then recruited to ribosomes, where with the obligatory aid of decoding tRNA, it is translated 50 to 30 to make proteins, amino t...