Comparative Studies on Creatine, Phosphorus, and Potassium in Various Muscle Tissues*
نویسنده
چکیده
Our present knowledge of the chemical behavior of creatine in muscle tissue rests largely upon the discovery of phosphocreatine by Fiske and Subbarow in 1927 (1). However, prior to this time there were many observations that suggested an interrelationship between creatine and other substances present in muscle. Urano (2) had already pointed out in 1906 the interesting fact that in experiments in vitro creatine and phosphate diffused from muscle at essentially the same rates, thus suggesting a connection between the two. In 1913, while working on the creatine content of rabbit muscle and its relation to urinary creatinine (3), it seemed probable to one of us (V. C. M.) that creatine was in some way linked with phosphorus, potassium, and glycogen in muscular activity, although in what way was not apparent. An attempt was made at that time to determine phosphorus and potassium as well as creatine in the muscle. The method for phosphorus did not prove entirely satisfactory, but a reliable method was available for potassium. A parallelism was noted between the muscle creatine and the potassium, but since no relationship seemed apparent at that time, the observations were not reported. However, in 1922, in writing a brief review (4) on muscle the conviction of a relationship between these substances was so strong that the statement was made, “Without further discussion it may be said that there are many observations which lead one to believe that
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Muscle Phosphorus in Nutritional Muscular Dystrophy in Rabbits*
Rabbits and guinea pigs upon certain diets develop an extreme degeneration of the skeletal muscles (15, 22). The onset of these muscle lesions may be delayed or prevented by the inclusion of vegetable oils in the diet (21, 26, 31) or by vitamin E concentrates (23). In dystrophic muscle the creatine content is lower than normal and roughly proportional to the amount of pathological degeneration ...
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