Pressure-Volume Loops in Clinical Research∗
نویسنده
چکیده
Left ventricular ejection fraction (EF) depends on ventricular contractility, afterload, and preload. Preload is related to end-diastolic volume (EDV) and pressure; the relationship between these 2 parameters (the end-diastolic pressurevolume relationship, EDPVR) indexes the degree of ventricular remodeling. Although EF is known to correlate with mortality in the subset of heart failure patients with reduced EF, it is previously unknown which of its determining factors contribute most importantly to prognosis. In this issue of the Journal, Ky et al. (1) set out to address this fundamental question using pressure-volume (PV) analysis, the most powerful approach for addressing such a problem.
منابع مشابه
Further observations on respiratory flow-volume loops: clinical evaluation of a new oral bronchodilator, CP-12,521-1.
PRESSUBE, VOLUME, AND FLOW DATA obtained during spirometry and plotted as pressure-volume or flow-volume loops have been used in the study of respiratory mechanics. Pressure-volume loops are used for the display of data generated in the measurement of static and dynamic compliance of the lungs and/or chest wall. 1-~ Flow-volume loops have been used for the quick pattern-recognition of various p...
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The end-systolic pressure-volume relationship (ESPVR) as derived from left ventricular pressure-volume loops has gained increasing acceptance as an index of ventricular contractile function. In animal experiments the ESPVR has been defined as a line connecting the upper left corners of several differently loaded pressure-volume (P-V) loops with a slope parameter Ees and a volume axis intercept ...
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