Targeting the Achilles Heel of Multidrug-Resistant Cancer by Exploiting the Fitness Cost of Resistance
نویسندگان
چکیده
Exploiting the Fitness Cost of Resistance Gergely Szakaćs,*,† Matthew D. Hall,‡ Michael M. Gottesman,‡ Ahceǹe Boumendjel, Remy Kachadourian, Brian J. Day, Heĺeǹe Baubichon-Cortay, and Attilio Di Pietro* †Institute of Enzymology, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Magyar tudośok körut́ja 2, Budapest 1117, Hungary ‡Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, United States Deṕartement de Pharmacochimie Molećulaire, Universite ́ de Grenoble/CNRS, UMR 5063 BP53, 38041 Grenoble Cedex 9, France Department of Medicine, National Jewish Health, Denver, Colorado 80206, United States Departments of Medicine and Pharmaceutical Sciences, University of Colorado Denver, Aurora, Colorado 80045, United States Equipe Labelliseé Ligue 2014, BMSSI UMR 5086 CNRS/Universite ́ Lyon 1, IBCP, 7 passage du Vercors, 69367 Lyon Cedex 07, France
منابع مشابه
Association of tcdA+/tcdB+ Clostridium difficile Genotype with Emergence of Multidrug-Resistant Strains Conferring Metronidazole Resistant Phenotype
Background: Reduced susceptibility of Clostridium difficile to antibiotics is problematic in clinical settings. There is new evidence indicating the cotransfer of toxin-encoding genes and conjugative transposons encoding resistance to antibiotics among different C. difficile strains. To analyze this association, in the current study, we evaluated the frequency of toxigenic C. difficile among th...
متن کاملMultidrug Resistance in Infants and Children
Bacterial infections may cause disease and death. Infants and children are often subject to bacterial infections. Antimicrobials kill bacteria protecting the infected patients andreducing the risk of morbidity and mortality caused by bacteria. The antibiotics may lose their antibacterial activity when they become resistant to a bacteria. The resistance to different antibiotics in a bacteria is ...
متن کاملCRISPR/Cas9, a new approach to successful knockdown of ABCB1/P-glycoprotein and reversal of chemosensitivity in human epithelial ovarian cancer cell line
Objective(s): Multidrug resistance (MDR) is a major obstacle in the successful chemotherapy of ovarian cancer. Inhibition of P-glycoprotein (P-gp), a member of ATP-binding cassette (ABC) transporters, is a well-known strategy to overcome MDR in cancer. The aim of this study was to investigate the efficiency and ability of CRISPR/Cas9 genome editing technology to knockdown ABCB1 gene expression ...
متن کاملThe Effect of Plant-derived Compounds in Targeting Cancer Stem Cells
Background Cancer stem cells (CSCs) are a small subpopulation of cancer cells with self-renewal and differentiation ability. Furthermore, CSCs are resistant to chemoradiotherapy due to their high level of detoxifying enzymes, strong DNA repair abilities, and high drug efflux capacity. Objective Therefore, CSCs are supposed to account for cancer initiation, progression, metastasis, recurrence, ...
متن کاملThe competitive cost of antibiotic resistance in Mycobacterium tuberculosis.
Mathematical models predict that the future of the multidrug-resistant tuberculosis epidemic will depend on the fitness cost of drug resistance. We show that in laboratory-derived mutants of Mycobacterium tuberculosis, rifampin resistance is universally associated with a competitive fitness cost and that this cost is determined by the specific resistance mutation and strain genetic background. ...
متن کامل