Response of a transplantable lymphosarcoma to colchicine.

Lits, Kirschbaum, and Strong (2), using a transplantable lymphosarcoma in mice, found that colchicine would apparently cause complete re gression in some animals but that recurrence in evitably occurred. One of the most successful at tempts in treating a transplanted lymphosarcoma was reported by Heilman and Kendall (3). They showed that Compound E (ll-dehydro-17-hydroxycorticosterone) produced complete regres sion in some mice bearing a transplantable lym phosarcoma; however, in most animals regression was not complete or if complete was only tem porary. Bass and Feigelson (4) demonstrated that colchicine is more effective than nitrogen mustard or urethan in producing acute regression of 6C3HED tumors in mice. In these studies, tumor regression was invariably observed following col chicine administration. The object of the present study was to extend these observations and to in vestigate the effects of prolonged administration of colchicine on this tumor.