Resistance to TB drugs in KwaZulu-Natal: causes and prospects for control

نویسندگان

  • Kristina Wallengren
  • Fabio Scano
  • Paul Nunn
  • Bruce Margot
  • Sandile Buthelezi
  • Brian Williams
  • Alex Pym
  • Elizabeth Samuel
  • Fuad Mirzayev
  • Wilfred Nkhoma
  • Lindiwe Mvusi
  • Yogan Pillay
چکیده

1. Freehouse International Ltd., Gibraltar 2. StopTB, World Health Organization, Geneva, Switzerland 3. Department of Health, KwaZulu-Natal, Pietermaritzburg, South Africa 4. South African Centre for Epidemiological Modelling and Analysis, Stellenbosch, South Africa 5. Medical Research Council, Durban, South Africa 6. Academic Complex Business Unit, Inkosi Albert Luthuli Central Hospital, National Health Laboratory Service, KwaZulu-Natal, South Africa. 7. World Health Organization, Regional Office for Africa, Harare, Zimbabwe 8. Department of Health, Pretoria, South Africa

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Future prospects for the MODS assay in multidrug-resistant tuberculosis diagnosis.

Extensively drug-resistant tuberculosis In 2004/2005, workers in Kwazulu-Natal, South Africa, became aware that some patients receiving effective antiretroviral therapy in their pioneering integrated HIV/tuberculosis (TB) program were dying despite undetectable HIV viral loads. Their subsequent detailed epidemiological study with enhanced surveillance for TB drug resistance finally blew the lid...

متن کامل

Spatial distribution of extensively drug-resistant tuberculosis (XDR TB) patients in KwaZulu-Natal, South Africa

BACKGROUND KwaZulu-Natal province, South Africa, has among the highest burden of XDR TB worldwide with the majority of cases occurring due to transmission. Poor access to health facilities can be a barrier to timely diagnosis and treatment of TB, which can contribute to ongoing transmission. We sought to determine the geographic distribution of XDR TB patients and proximity to health facilities...

متن کامل

Combined antiretroviral and anti-tuberculosis drug resistance following incarceration.

We describe a case of HIV/tuberculosis (TB) co-infection from KwaZulu-Natal, South Africa, characterised by drug resistance in both pathogens. The development of drug resistance was linked temporally to two periods of incarceration. This highlights the urgent need for improved integration of HIV/TB control strategies within prison health systems and within the broader public health framework.

متن کامل

Microbial and Chemical Adulterants Assessment of Raw Cow Milk Collected from Dairy Farms of Hlabisa Villages, KwaZulu-Natal Province, South Africa

Background: Milk is one of the most nutritious foods providing a variety of proteins, fats, minerals, and vitamins needed to maintain, grow, and develop the body. The aim of this study was to assess microbial and chemical adulterants of raw cow milk collected from dairy farms of Hlabisa villages, KwaZulu-Natal Province, South Africa. Methods: A total of 68 raw cow milk samples were obtained fr...

متن کامل

High Prevalence of inhA Promoter Mutations among Patients with Drug-Resistant Tuberculosis in KwaZulu-Natal, South Africa

BACKGROUND Drug-resistant tuberculosis (TB) remains extremely difficult to treat because there are often few remaining active medications and limited diagnostic options to detect resistance. Resistance to isoniazid is typically caused by mutations in either katG or the inhA promoter. inhA mutations confer low-level resistance to isoniazid and cross-resistance to ethionamide while katG mutations...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2011