A New Method for the Syntiiesis of 1-Aryl Phthalazines
نویسندگان
چکیده
A simple versatile method for the conversion of benzy1idene)-hydrazines to 1 -aryl-phthalazines using polyphosphate ester (PPE) is described 1 -aroyl-2-( substituted Podophyllotoxin ( I ) , a cytotoxic constituent of the plant species podophyllum peltatum has attracted considerable research activities, which culminated in the synthesis of tenoposides, and etoposides, which are now clinically used as antitumor agents' * CH ' H3
منابع مشابه
Synthesis and anticancer activities of novel 1,4-disubstituted phthalazines.
A series of novel 1-anilino-4-(arylsulfanylmethyl)phthalazines were designed and synthesized. The structures of all the compounds were confirmed by IR, 1H-NMR, elemental analysis and MS. The analogues 1-(3-chloro-4-fluoroanilino)-4-(3,4- difluorophenylthio-methyl)phthalazine (12) and 1-(4-fluoro-3-trifluoromethylanilino)-4- (3,4-difluorophenyl-thiomethyl)phthalazine (13) showed higher activity ...
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