Low-frequency repetitive transcranial magnetic simulation prevents chronic epileptic seizure
نویسندگان
چکیده
Although low-frequency repetitive transcranial magnetic simulation can potentially treat epilepsy, its underlying mechanism remains unclear. This study investigated the influence of low-frequency re-petitive transcranial magnetic simulation on changes in several nonlinear dynamic electroence-phalographic parameters in rats with chronic epilepsy and explored the mechanism underlying petitive transcranial magnetic simulation-induced antiepileptic effects. An epilepsy model was es-tablished using lithium-pilocarpine intraperitoneal injection into adult Sprague-Dawley rats, which were then treated with repetitive transcranial magnetic simulation for 7 consecutive days. Nonlinear electroencephalographic parameters were obtained from the rats at 7, 14, and 28 days post-stimulation. Results showed significantly lower mean correlation-dimension and Kolmogo-rov-entropy values for stimulated rats than for non-stimulated rats. At 28 days, the complexity and point-wise correlation dimensional values were lower in stimulated rats. Low-frequency repetitive transcranial magnetic simulation has suppressive effects on electrical activity in epileptic rats, thus explaining its effectiveness in treating epilepsy.
منابع مشابه
Effect of different frequencies of repetitive transcranial magnetic stimulation (rTMS) on acquisition of chemical kindling seizures in rats
IIntroduction: Repetitive transcranial magnetic stimulation (rTMS) modulates the excitability of cortical neural networks. The effect of rTMS on excitability of cortical networks depends on its frequency. According to the previous reports, a distinction is made between low (<1Hz) and high frequencies of rTMS. Low frequencies of rTMS inhibit seizure but high frequencies increase it. In the curre...
متن کاملH-coil repetitive transcranial magnetic stimulation for treatment of temporal lobe epilepsy: A case report
Low frequency repetitive TMS (rTMS) of a cortical seizure focus is emerging as an antiepileptic treatment. While conventional rTMS stimulators activate only superficial cortical areas, reaching deep epileptic foci, for example in temporal lobe epilepsy (TLE), is possible using specially designed H-coils. We report the results of rTMS in a young adult with pharmacoresistant bilateral TLE who und...
متن کاملThe effect of combining low frequency repetitive trans-cranial magnetic stimulation and conventional rehabilitation in improving functional behavior of hemiplegic patients
Purpose: Some new methods of treatment focus on using magnetic stimulation as a means of induction currents in the brain to produce therapeutic effects. The aim of this clinical trial was to determine the effects of repetitive transcranial magnetic stimulation (rTMS) plus routine rehabilitation on hand grip and wrist motor function in hemiplegic patients.Materials and Methods: Twelve hemiplegic...
متن کاملLow-frequency repetitive transcranial magnetic stimulation for seizure suppression in patients with extratemporal lobe epilepsy—A pilot study
We evaluated the effect of low-frequency repetitive transcranial magnetic stimulation (rTMS) on seizure frequency in adult patients with medically intractable extratemporal lobe epilepsy (ETLE). Seven patients with medically intractable ETLE received low-frequency rTMS at 0.9 Hz, basically two sets of 15 min stimulation per day for five days in a week, with the stimulus intensity of 90% of rest...
متن کاملInvestigating the Effects of Low Frequency rTMS on Kindled Seizure in Rats
Introduction: Neural stimulation is a promising new technology for the treatment of medically-intractable seizures. Transcranial Magnetic Stimulation (TMS) is a simple, non-invasive, low cost technique which is widely used in neurophysiology. In a few studies that have been performed at different frequencies the therapeutic effects of this technique were not obvious. Repetition of low frequen...
متن کامل