Very Low HbA1c Values in A Patient with Clinical Silent Hemoglobin Variant ( Hemoglobin J ) A Case Report
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چکیده
Glycohemoglobin (GHb) most accurately reflects the previous two to three months of glycemic control. According to the American Diabetes Association, GHb should be measured regularly in all patients with diabetes, and values should be maintained below 7% to prevent the risk of chronic complications. Herein, we report a case of a 71-year-old type 2 diabetic female patient with extraordinary low HbA1c values. The hemoglobin electrophoresis identified the existence of Hemoglobin (Hb) variant Hb J. Our case study emphasized that clinical laboratories should be aware of limitations of their HbA1c assay methods as well as the importance of visual inspection of ion exchange chromatograms to detect abnormalities caused by Hb variants. ( J Intern Med Taiwan 2007; 18: 45-50 )
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