Children with Sex Chromosome Aneuploidy: Follow-Up Studies

The third chapter reviews the pharmacologic properties of antiplatelet drugs and the antiplatelet effects of drugs used in general medical practice. The drugs discussed include aspirin, non-steroidal anti-inflammatory agents, sulfinpyrazone, prostaglandins PGE1 and PGI2, dipyridamole, and other pyridamole-pyrimidine compounds. Especially helpful is a section on the effects of anesthetics, major tranquilizers , antihistamines, penicillins, dextran, diuretics, propranolol, and an-ticoagulants on platelets and the platelet membrane. The fourth chapter discusses antiplatelet drugs in clinical medicine and reviews the various clinical trials. The author also examines the literature on the possible beneficial effects of aspirin for patients with ischemic heart disease and cerebral vascular disease. Furthermore there is a section on the effects of antiplatelet drugs on thromboembolism associated with prosthetic devices, artificial surfaces, and vascular shunts. The bibliography is extensive, with many post-1980 references; some are as late as 1982, the year of publication. The book is well written and easy to read. The author, an internationally known expert in the field, has done an admirable job of reviewing a very large literature. One of the problems associated with this book is that some areas are reviewed in a cursory manner. For example, the section on platelet granules is small, and individuals wishing to learn the latest information about a-granules and dense granules would be best referred to another source. Another deficiency is that there is little in this book relating to thrombocytopenia. The number of tables and figures are relatively small, and the book would have benefited from more liberal use of these visual aids. This book would be of limited value to established researchers in the field since much of the material presented is covered in a superficial manner. General inter-nists, young investigators, and medical students interested in platelet function, however, would find this book to be relatively inexpensive and a most useful addition to their medical libraries. For a general overview of platelet function and as a reference source, this little volume is made to order. reviews progress since the 1977 meeting of a group of investigators from nine medical centers conducting ongoing investigations of children with recognized chromosome abnormalities, identified by newborn screening. This collection represents an effort to understand the impact of chromosome abnormalities on growing children as well as the impact of identifying these abnormalities in the neonatal period via a screening tool rather than ascertainment based on clinical abnormalities. This type of data ascertainment …