Successful Pregnancy and Delivery After Radiation With Ovarian Shielding for Acute Lymphocytic Leukemia Before Menarche
نویسندگان
چکیده
Total body irradiation is performed as a preconditioning regimen to inhibit graft-versus-host disease after bone marrow transplantation and to eradicate remaining tumor cells. However, these regimens result in delayed secondary sex characteristics and failure of ovarian function recovery, leading to amenorrhea and infertility. Herein, we report a case of an 11-year-old girl diagnosed with acute lymphocytic leukemia who received induction chemotherapy and prophylactic cranial irradiation. For bone marrow transplantation, she received total body irradiation of 12 Gy with uterine and ovarian shielding at 13 years of age. The patient remained in remission and menarche began at 14 years of age. At 23, she became pregnant and delivered a baby naturally with no abnormalities.
منابع مشابه
Effect of Probiotics on Salivary Flow Rate and pH in Children with Acute Lymphocytic Leukemia (ALL) During Chemotherapy
Background: This study was performed to evaluate the effects of probiotics on salivary flow rate and pH in children with Acute Lymphocytic Leukemia (ALL) during chemotherapy. Methods: A randomized clinical trial was conducted on 11 children with ALL on induction and consolidation phases of chemotherapy. At the beginning, clinical examination of the oral mucosa and dental hygiene and intervie...
متن کاملA Fuzzy-GA Approach for Parameter Optimization of A Fuzzy Expert System for Diagnosis of Acute Lymphocytic Leukemia in Children
Hybrid fuzzy expert systems are one of the most practical intelligent paradigm of soft computing techniques with the high potential for managing uncertainty associated to the medical diagnosis. The potential of genetic algorithm (GA) by inspiring from natural evolution as a learning and optimization technique has been vastly concentrated for improving fuzzy expert systems. In this paper, the GA...
متن کاملAfter the deluge: the emerging landscape of childbearing potential in pediatric cancer survivors.
Journal of the National Cancer Institute, Vol. 98, No. 20, October 18, 2006 A woman’s ability to become pregnant, carry the pregnancy successfully, and give birth to a healthy child are all paradoxically threatened by many of the cancer treatments that enable girls to survive to adulthood. Like Hurricane Katrina, pediatric cancer is a tempest that leaves a concealing fl ood of acute treatment e...
متن کاملA Fuzzy Expert System for Diagnosis of Acute Lymphocytic Leukemia in Children
Fuzzy expert systems are one of the most practical intelligent models with the high potential for managing uncertainty associated to the medical diagnosis. In this paper, a fuzzy inference system (FIS) for diagnosing of acute lymphocytic leukemia in children has been introduced. The fuzzy expert system applies Mamdani reasoning model that has high interpretability to explain system results to e...
متن کاملOral Ciprofloxacin Compared with Intravenous Ceftazidim on Low Risk Febrile Neutropenia in Acute Lymphocytic Leukemia
Abstract Objective Fever and neutropenia are a common complication of chemotherapy in cancer. It is usually managed by hospitalization and empiric administration of antibiotics. Use of Fluroquinolones is limited because of joint/cartilage toxicity. This study attempted to compare the efficacy of oral ciprofloxacin with intravenous ceftazidim in low risk febrile neutropenic lymphocytic leukemi...
متن کامل