Recognition of forcible curvature in circular DNA by human Topoisomerase I.
نویسندگان
چکیده
A series of forcible curved circular DNAs (cDNAs) were prepared to investigate the recognition features of human Topoisomerase I (hTopo I). The IC(50) can be modulated by the curvature degrees of cDNA. In addition, preferential bindings of hTopo I to cDNA with high curvature have been observed by AFM and EMSA.
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ورودعنوان ژورنال:
- Chemical communications
دوره 47 40 شماره
صفحات -
تاریخ انتشار 2011