Antiherpetic mode of action of (22S,23S)-3 -bromo-5 ,22,23-trihydroxystigmastan-6-one in vitro
نویسندگان
چکیده
The replication of herpes simplex virus (HSV) type 1 in Vero cells is inhibited in the presence of (22S,23S)-3 -bromo-5 ,22,23-trihydroxystigmastan-6-one (6b), a synthetic brassinosteroid derivative. Attempts to disclose the mode of action of 6b indicate that a late step of virus multiplication is affected. In the presence of 6b, HSV late protein synthesis was severely diminished and this inhibitory effect of 6b on HSV antigen expression was confirmed by immunofluorescence assays. © 2004 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.
منابع مشابه
In vitro and in vivo antiherpetic activity of three new synthetic brassinosteroid analogues.
Brassinosteroids are a novel group of steroids that appear to be ubiquitous in plants and are essential for normal plant growth and development. It has been previously reported that brassinosteroid analogues exert an antiviral activity against herpes simplex virus type 1 (HSV-1) and arenaviruses. In the present study, we report the chemical synthesis of compounds (22S,23S)-3beta-bromo-5alpha,22...
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