RETRACTED: radish Encodes a Phospholipase-A2 and Defines a Neural Circuit Involved in Anesthesia-Resistant Memory
نویسندگان
چکیده
Institute of Biotechnology One of the defining characteristics of memory is that Hsinchu 30043 initially it is labile, but with time it can be consolidated Taiwan to a longer-lasting form that is resistant to disruption. 2 Cold Spring Harbor Laboratory Immediately after training, for instance, memory can be 1 Bungtown Road disrupted by a variety of anesthetic agents or by electroCold Spring Harbor, New York 11724 convulsive shock [1–7]. Within several hours, however, 3 Watson School of Biological Sciences the effects of these treatments are greatly diminished. Cold Spring Harbor Laboratory Although the appearance of anesthesia-resistant 1 Bungtown Road forms of memory has been documented in marine inverCold Spring Harbor, New York 11724 tebrates [8, 9], several insect species [2, 10–13], chicks 4 Division of Informatics [14], rodents [15], and humans [16], a genetic disruption Institute for Adaptive and Neural Computation of ARM has been accomplished only in Drosophila. In University of Edinburgh radish (rsh) mutants, ARM is defective, and learning 5 Forrest Hill (memory immediately after training) is diminished, but Edinburgh EH1 2QL CREB-dependent LTM is normal [10–12, 17, 18]. ARM United Kingdom decays completely within 4 days and is not blocked by 5 Brain Research Center inhibitors of protein synthesis, whereas LTM lasts more University System of Taiwan than one week and depends on protein synthesis. ARM Hsinchu 30043 also is behaviorally distinct from LTM because it is inTaiwan duced after a single training session or after repetitive
منابع مشابه
radish Encodes a Phospholipase-A2 and Defines a Neural Circuit Involved in Anesthesia-Resistant Memory
BACKGROUND In both vertebrate and invertebrate animals, anesthetic agents cause retrograde amnesia for recently experienced events. In contrast, older memories are resistant to the same treatments. In Drosophila, anesthesia-resistant memory (ARM) and long-term memory (LTM) are genetically distinct forms of long-lasting memory that exist in parallel for at least a day after training. ARM is disr...
متن کاملThe Drosophila radish gene encodes a protein required for anesthesia-resistant memory.
Long-term memory in Drosophila is separable into two components: consolidated, anesthesia-resistant memory and long-lasting, protein-synthesis-dependent memory. The Drosophila memory mutant radish is specifically deficient in anesthesia-resistant memory and so represents the only molecular avenue to understanding this memory component. Here, we have identified the radish gene by positional clon...
متن کاملAltered gene regulation and synaptic morphology in Drosophila learning and memory mutants.
Genetic studies in Drosophila have revealed two separable long-term memory pathways defined as anesthesia-resistant memory (ARM) and long-lasting long-term memory (LLTM). ARM is disrupted in radish (rsh) mutants, whereas LLTM requires CREB-dependent protein synthesis. Although the downstream effectors of ARM and LLTM are distinct, pathways leading to these forms of memory may share the cAMP cas...
متن کاملThe Radish Gene Reveals a Memory Component with Variable Temporal Properties
Memory phases, dependent on different neural and molecular mechanisms, strongly influence memory performance. Our understanding, however, of how memory phases interact is far from complete. In Drosophila, aversive olfactory learning is thought to progress from short-term through long-term memory phases. Another memory phase termed anesthesia resistant memory, dependent on the radish gene, influ...
متن کاملSerotonin-mushroom body circuit modulating the formation of anesthesia-resistant memory in Drosophila.
Pavlovian olfactory learning in Drosophila produces two genetically distinct forms of intermediate-term memories: anesthesia-sensitive memory, which requires the amnesiac gene, and anesthesia-resistant memory (ARM), which requires the radish gene. Here, we report that ARM is specifically enhanced or inhibited in flies with elevated or reduced serotonin (5HT) levels, respectively. The requiremen...
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ورودعنوان ژورنال:
- Current Biology
دوره 14 شماره
صفحات -
تاریخ انتشار 2004