Wilkinson G R 377-90, 1975
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چکیده
This paper described a pharmacokinetic model for the hepatic elimination of drugs based on the relationship between the involved physiological factors including the new concept of "intrinsic clearance." It was shown that such a unifying model could describe the known effects of perturbations in the determinants on a drug's blood concentration-time profile caused by disease-states, drug interactions, interindividual variability in drug metabolizing ability, and route of administration. A generalizable classification was developed that allowed prediction of in vivo disposition characteristics according to the particular drug's intrinsic clearance. [The SCI indicates that this paper has been cited in more than 1,335 publications, making it the most-cited paper published in this journal]
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Frusemide in respiratory distress syndrome.
Savage, M. O., Wilkinson, A. R., Baum, J. D., Roberton, N. R. C. (1975). Archives of Disease in Childhood, 50, 709. Frusemide in respiratory distress syndrome. The effect of frusemide on urinary volume, urinary sodium excretion, and urinary calcium excretion in 7 premature infants with severe respiratory distress syndrome (RDS) has been studied. The results are compared with similar measurement...
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Hegsted, D. M., Gotsis, L. & Stare, F. J. (1957). J. Nutr. 63, 377. Herb, S. F. & Riemenschneider, R. W. (1953). Analyt. Chem. 25, 953. Hilditch, T. P. (1956). Chemical Constitution of Natural Fat8, 3rd ed. London: Chapman and Hall Ltd. Hilditch, T. P., Ichaporia, M. B. & Jasperson, H. (1938). J. Soc. chem. Ind., Lond., 57, 363. Keys, A., Anderson, J. T. & Grande, F. (1957). Lancet, i, 66, 787....
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