Comment on "Remeasuring the double helix".

Remeasuring the double helix.

DNA is thought to behave as a stiff elastic rod with respect to the ubiquitous mechanical deformations inherent to its biology. To test this model at short DNA lengths, we measured the mean and variance of end-to-end length for a series of DNA double helices in solution, using small-angle x-ray scattering interference between gold nanocrystal labels. In the absence of applied tension, DNA is at...

Can we model DNA at the mesoscale ? Comment on: Fluctuations in the DNA double helix: A critical review

Comment on "Why is the DNA denaturation transition first order?".

1 Comment on " Why is the DNA denaturation transition first order? " Recently, Kafri, Mukamel and Peliti (KMP) [1] extended the classical Poland-Scheraga (PS) model for the denaturation transition of DNA [2]. According to PS, the energetic binding of bases in the double helix competes with the entropic contribution of denatured loops, implying that the nature of the transition depends on the ex...

Recent advances on nano delivery of Helix mucus pharmacologically active components

Bioactive products from snail slime of “Helix” specie have potential applications in preventing and/or treating several human diseases and in cancer diagnosis. However, the poor pharmacokinetics characteristics of these natural compounds limit their use. Nanotechnology offers promising solutions for the enhanced formulation of these molecules through the synthesis of nanosized drug del...

Fluctuations in the DNA double helix: A critical review.

A critical overview of the extensive literature on fluctuations in the DNA double helix is presented. Both theory and experiment are comprehensively reviewed and analyzed. Fluctuations, which open up the DNA double helix making bases accessible for hydrogen exchange and chemical modification, are the main focus of the review. Theoretical descriptions of the DNA fluctuations are discussed with s...