Carbenoxolone, a Gap Junction Blocker, Enhances Antinociceptive Effects of Morphine in Formalin Test in Mice
نویسندگان
چکیده
In this study, the antinociceptive effects of the gap junction blocker carbenoxolone and morphine were examined using the formalin test as a model of pain. We found that carbenoxolone was dose-dependently antinociceptive in both the first and second phases of the formalin test. Pretreatment with carbenoxolone increased antinociceptive effect of morphine in the first phase of formalin test. Also, pretreatment of carbenoxolone at lower dose of morphine could enhance antinociceptive effect of it in the second phase of formalin test. It is possible that gap junction blockade may be involved in the antinociceptive activity of carbenoxolone.
منابع مشابه
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