Compressive Sensing Ensemble Average Propagator Estimation via `1 Spherical Polar Fourier Imaging

In diffusion MRI (dMRI) domain, many High Angular Resolution Diffusion Imaging (HARDI) methods were proposed to estimate Ensemble Average Propagator (EAP) and Orientation Distribution Function (ODF). They normally need many samples, which limits their applications. Some Compressive Sensing (CS) based methods were proposed to estimate ODF in Q-Ball Imaging (QBI) from limited samples. However EAP estimation is much more difficult than ODF in QBI. Recently Spherical Polar Fourier Imaging (SPFI) was proposed to represent diffusion signal using Spherical Polar Fourier (SPF) basis without specific assumption on diffusion signals and analytically obtain EAP and ODF via the Fourier dual SPF (dSPF) basis from arbitrarily sampled signal. Normally the coefficients of SPF basis are estimated via Least Square with weighted `2 norm regularization (`2-SPFI). However, `2-SPFI needs a truncated basis to avoid overfitting, which brings some estimation errors. By considering the Fourier relationship between EAP and signal and the Fourier basis pair provided in SPFI, we propose a novel EAP estimation method, named `1-SPFI, to estimate EAP from limited samples using CS technique, and favorably compare it to the classical `2-SPFI method. `1-SPFI estimates the coefficients in SPFI using least square with weighted `1 norm regularization. The weights are designed to enhance the sparsity. `1-SPFI significantly accelerates the ordinary CS based Fourier reconstruction method. This is performed by using SPF basis pair in CS estimation process which avoids the numerical Fourier transform in each iteration step. By considering high order basis in `1 optimization, `1-SPFI improves EAP reconstruction especially for the angular resolution. The proposed `1-SPFI was validated by synthetic, phantom and real data. The CS EAP and ODF estimations are discussed in detail and we show that recovering the angular information from CS EAP requires much less samples than exact CS EAP reconstruction. Various experiments on synthetic, phantom and real data validate the fact that SPF basis can sparsely represent DW-MRI signals and `1-SPFI largely improves the CS EAP reconstruction especially the angular resolution.