Hepatic MR Imaging for Differentiation of Biopsy-Proven Steatosis, Iron Deposition, and Combined Disease: One- Dimensional In / Opposed Phase Analysis vs. Two-Dimensional Computer-aided Dixon Discrimination

Steatosis hepatis functions as an inducer of hepatic iron metabolism dysregulation. MR two-point Dixon T1w imaging with subsequent comprehensive four-phase decomposition analysis facilitated not only metabolite decomposition of intrahepatic lipids and iron ions in steatosis hepatis and hepatic iron overload, but also allowed decomposition of metabolites in combined disease in an in-vivo patient population employing manual as well as computer-aided two-dimensional metabolite discrimination algorithms, with liver biopsy functioning as reference standard.